Software to Design Crosslinks for Protein Crystal Stabilization
Programmable materials allow properties as specific locations in the material to be modified through reliable encoding. One class of such materials are protein crystals that allow changes to be made through genetic manipulation. Protein crystals are well-ordered and highly porous materials, but they are also easily dissolved, limiting their utility. Crosslinking techniques previously developed often have a deleterious effects on the crystal order. In this work, we introduce software to design specific crosslinks across protein crystal interfaces using disulfide and dityrosine crosslinks as well ...