Microbiology, Immunology, and Pathology
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Extrinsic and intrinsic drivers of feline immunodeficiency virus evolution in the mountain lion
Viruses are among the most rapidly evolving entities in biology and are so intricately associated with their obligate hosts that the boundary between host and pathogen, and thus the study of one versus the other, is blurred ... -
T zone lymphoma : cellular origin and function
The lymphoid system is exceedingly complex with specialized subsets of lymphocytes involved in both the innate and adaptive immune response. Lymphocytes are subdivided into T cells and B cells with lymphoproliferative ... -
Exploration of viral RNA-mediated strategies to stall and repress the cellular exoribonuclease XRN1, An
The regulation of mRNA decay plays a vital role in determining both the level and quality control of cellular gene expression in eukaryotes. Since they are likely recognized as foreign/unwanted transcripts, viral RNAs must ... -
Roles of iron, the infrapatellar fat pad, and dietary factors in the Hartley guinea pig model of spontaneous osteoarthritis, The
Osteoarthritis (OA) is the most prevalent musculoskeletal disorder across the world, affecting close to 300 million people. The disease manifests as degeneration and loss of articular cartilage, synovial hyperplasia, ... -
Characterization of changes in metabolic pathways during dengue virus serotype 2 infection of the Aedes aegypti mosquito vector to identify control points for interrupting virus transmission
Dengue viruses (DENV) are mosquito-borne viruses that cause a wide range of acute symptoms from mild fever to lethal dengue shock syndrome in humans. DENV are transmitted primarily by Aedes aegypti (Ae. aegypti). These ... -
Flavivirus control of lipid metabolism : implications for virion formation, function and pathogenesis
Dengue viruses (DENV) are the most aggressive arthropod-born viruses worldwide with no currently available antivirals. There is a clear need to understand host viral interactions that can be exploited for therapeutic ... -
Innate and adaptive immune responses after bovine viral diarrhea virus infection in the fetal thymus
Bovine viral diarrhea virus (BVDV) infection of bovine fetuses in the first 125 days of pregnancy results in persistently infected (PI) cattle and transiently infected (TI) cattle become infected, but have a developed ... -
Cleavage of exosomal-associated transferrin receptor in dogs, cats, and horses : progress towards a soluble transferrin receptor assay
Iron deficiency anemia and anemia of chronic disease are two complications that patients in human medicine as well as veterinary medicine often encounter. These two diseases usually occur secondary to other primary diseases ... -
Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos
Mycobacterium leprae (M. leprae) is a human pathogen and the causative agent for leprosy, a chronic disease characterized by lesions of the skin and peripheral nerve damage. Zoonotic transmission of M. leprae to humans by ... -
Ivermectin-treated bird feed to control West Nile virus transmission
West Nile virus is the leading cause of arboviral fever and encephalitis in the United States. The highest WNV disease incidence occurs along the Great Plains region of the United States, as the ecology and land use provide ... -
Role of prion protein glycosylation in prion propagation, The
Transmissible Spongiform Encephalopathies (TSEs) are a group of neurodegenerative diseases that affect humans and animals alike. TSEs are caused by the accumulation of a disease producing isoform referred to as PrPSc that ... -
Bats as reservoir hosts : exploring novel viruses in New World bats
To view the abstract, please see the full text of the document. -
Applications of feline immunodeficiency virus as a model to study HIV pathogenesis
Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, and produces progressive immune depletion that eventually results in an acquired immunodeficiency ... -
Exosomes : a potential novel source of biomarkers for Tuberculosis
To view the abstract, please see the full text of the document. -
Binding of MBNL1 to CUG repeats slows 5'-to-3' RNA decay by XRN2 in a cell culture model of type I myotonic dystrophy
Type I myotonic dystrophy (DM1) is a multi-systemic inherited disease caused by expanded CTG repeats within the 3' UTR of the dystrophia myotonica protein kinase (DMPK) gene. The encoded CUG repeat-containing mRNAs are ... -
Crossing the blood-brain barrier : siRNA treatment for prion diseases
Protein misfolding diseases such as prion diseases, Alzheimer's disease, and Parkinson's disease, are fatal neurodegenerative diseases caused by a misfolded protein. There are no known therapeutics that extend survival ... -
Longitudinal characterization of peripheral prion pathogenesis in Syrian hamsters experimentally inoculated with hamster-adapted Transmissible Mink Encephalopathy
Transmissible Spongiform Encephalopathies (TSEs) are a group of infectious, neurodegenerative diseases affecting animals, including humans. Caused by misfolded proteins called prions, TSEs are characterized by a long, ... -
Mexican mosquitoes : overcoming barriers for dengue and Zika virus infection
The mosquito transmitted arboviruses cause an important burden of disease worldwide. In Latin America dengue disease is endemic with more than 1 million dengue fever cases reported yearly. In addition to dengue, chikungunya ... -
Changes in autoreactive B cell lifestyle early in development of autoimmunity
Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells, leading to decreased production of insulin and hyperglycemia. Although environmental factors contribute, genetic ... -
Pathogenesis of oral FIV infection
Feline immunodeficiency virus (FIV) is the feline analogue of human immunodeficiency virus (HIV) and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While ...
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