Department of Microbiology, Immunology, and Pathology
These digital collections include theses, dissertations, and faculty publications from the Department of Microbiology, Immunology, and Pathology. Due to departmental name changes, materials from the following historical departments are also included here: Microbiology.
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Medical and molecular virology
This book was created for upper division microbiology students studying virology. It will describe the molecular biology and major diseases of virus families that cause significant disease in animals and humans. This book ... -
Immune modulatory and antimicrobial properties of mesenchymal stromal cells delivered systemically
To view the abstract, please see the full text of the document. -
Targeted computational analysis of the C3HEB/FEJ mouse model for drug efficacy testing
Efforts to develop effective and safe drugs for the treatment of tuberculosis (TB) require preclinical evaluation in animal models. Alongside efficacy testing of novel therapies, effects on pulmonary pathology and disease ... -
Molecular characterization of novel transcription of antisense toxin-antitoxin RNA in regulating Mycobacterium tuberculosis
Despite more than seventy years of available anti-tuberculosis (TB) treatments, Mycobacterium tuberculosis (Mtb) remains the deadliest human pathogen. Novel short-course therapies are needed that effectively treat latent ... -
Permethrin resistance status and associated mechanisms in Aedes albopictus mosquitoes: implications for vector control
There are major public health concerns regarding the spread of mosquito-borne diseases such as dengue, Zika, and chikungunya. The primary method to reduce the spread of these diseases is by killing the major mosquito ... -
Understanding the process of Mycobacterium abscessus reinfection on host immunity
Mycobacterium abscessus is a bacterial pathogen emerging in humans. The bacterium is difficult to treat, and it results in increased mortality. The patient case rates of diseases associated with this bacterium are increasing. ... -
Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection
Feline infectious peritonitis (FIP) is a disease with high mortality that results from a mutation in the genome of the relatively harmless and ubiquitous feline coronavirus (FCoV) (Licitra, Millet et al. 2013). FIP causes ... -
Comparative physiology of Mycobacterium abscessus in synthetic laboratory medium and cystic fibrosis sputum
Mycobacterium abscessus complex is a group of rapid-growing nontuberculous mycobacteria that are multidrug resistant and that cause chronic pulmonary infections in individuals with cystic fibrosis (CF) and other pre-disposing ... -
Inhalational antibiotic therapy for treatment of chronic pulmonary Mycobacterium abscessus disease in mice
Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes chronic pulmonary infections. Due to M. abscessus's intrinsic antibiotic resistance, treatment is often complex with low cure rates. ... -
Epidemiological investigation of antimicrobial resistance in beef production using metagenomic sequencing
Globally, the emergence of antimicrobial resistance (AMR) resulting in treatment failure is recognized as a growing public health threat. Antimicrobial use practices used in beef production are thought to be a direct driver ... -
Characterizing the genetic evolution of endemic bluetongue virus strains
Bluetongue virus is an arthropod-borne virus that can cause severe disease in susceptible animals. Transmitted by biting midges in the genus Culicoides, the bluetongue virus particle (genus Orbivirus, family Reoviridae) ... -
Biofilm dynamics and the response to N-oxides in Burkholderia pseudomallei
Burkholderia pseudomallei is a saprophytic bacterium inhabiting wet soils in tropical regions and is the causative agent of melioidosis, an emerging infectious disease of high mortality. Although the incidence of melioidosis ... -
Use of metagenomic sequencing as a tool for pathogen discovery with further investigation of novel reptilian serpentoviruses, The
To view the abstract, please see the full text of the document. -
Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
Endogenous retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they ... -
MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria, The
Integral membrane transporters of the Mycobacterial Membrane Protein Large (MmpL) family and their interactome play important roles in the synthesis and export of mycobacterial outer membrane lipids. Despite the current ... -
Pathogenesis and immunological response of Yersina pestis in carnivores
Yersinia pestis is the causative agent of plague. The pathogen is endemic in rodent populations in the western United States where humans and other mammals become infected with this highly virulent organism when exposed ... -
Evolution of mutations associated with pyrethroid resistance and the reversal of resistance in Aedes aegypti
Worldwide vector control has been relying heavily on pyrethroid insecticides to reduce Aedes aegypti Linnaeus populations. Pyrethroids are relatively inexpensive, have low vertebrate toxicity, and have been efficient in ... -
Understanding Mycobacterium abscessus in cystic fibrosis mice
Cystic fibrosis (CF) is caused by mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which normally encodes an ABC transporter-class ion channel protein that allows chloride and thiocyanate ... -
Female- and intruder-induced ultrasonic vocalizations as proxy indicators for animal well-being and postoperative pain recognition in C57BL/6J mice
Mice are the most commonly used research animal and often undergo painful procedures. It is important to minimize pain and distress in research animals. However, recognizing pain and distress in mice is challenging. There ... -
Feline foamy virus in domestic cats: use as a vaccine vector, characterization of infection, and association with other diseases
Foamy viruses (FVs) are retroviruses from the Spumaretrovirinae subfamily. FVs are globally prevalent retroviruses with a unique molecular biology. FVs establish apparently apathogenic lifelong infections. Due to this, FVs ...
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