Department of Microbiology, Immunology, and Pathology
These digital collections include theses, dissertations, faculty publications, and datasets from the Department of Microbiology, Immunology, and Pathology. Due to departmental name changes, materials from the following historical departments are also included here: Microbiology.
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Recent Submissions
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Illustrating the post-introduction ecology of Rift Valley fever virus in the United States of America
Rapid urbanization, increasing international travel, and our changing climate are modifying the existing interspecies interactions at the interfaces between human, wildlife, and livestock interfaces, increasing the potential ... -
From BCG vaccination routes to lung and gut microbiota: avenues to tackle Mycobacterium tuberculosis infection
Tuberculosis is an infectious lung disease responsible for approximately 1.4 million human deaths, world-wide every year. The causal agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), has been estimated ... -
Chronic wasting disease strain diversity, distribution and transmission
Chronic wasting disease (CWD) is an invariably fatal prion disease affecting captive and free-ranging cervids, including white-tailed deer, mule deer, moose, elk and reindeer. Since the initial discovery of the disease in ... -
Assessment of mosquito and animal model factors in Aedes-borne arbovirus transmission and disease
To view the abstract, please see the full text of the document. -
Iron, hepcidin, and microcytosis in canine hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver tumor found in dogs. There is evidence that iron dysregulation is associated with HCC pathogenesis in both humans and dogs. Anemia and thrombocytosis were ... -
Characterization of grcC1 and grcC2 prenyl diphosphate synthases potentially involved in menaquinone synthesis in Mycobacterium tuberculosis, and a homologous enzyme (ms1133) in Mycobacterium smegmatis
Characterization of GrcC1 and GrcC2 prenyl diphosphate synthases potentially involved in menaquinone synthesis in Mycobacterium tuberculosis, and a homologous enzyme (MS1133) in Mycobacterium smegmatis Biosynthesis pathways ... -
Of bats and bugs: characterizing arboviral transmission at the human-wildlife interface
To view the abstract, please see the full text of the document. -
Comprehensive approach to modeling musculoskeletal aging and injury, A: an emphasis on Nrf2-related pathogenesis
Osteoarthritis (OA) is a degenerative joint disease that affects over 730 million people globally, over 30 million Americans, and is the leading cause of disability in adults. The underlying pathogenesis is multifactorial ... -
Explorations in West Nile virus ecology and evolution
West Nile virus (WNV) continues to be a major cause of human arboviral neuroinvasive disease. Susceptible non-human vertebrates are particularly diverse, ranging from commonly affected birds and horses to less commonly ... -
Modern considerations for the use of naive Bayes in the supervised classification of genetic sequence data
Genetic sequence classification is the task of assigning a known genetic label to an unknown genetic sequence. Often, this is the first step in genetic sequence analysis and is critical to understanding data produced by ... -
From Retroviridae to Flaviviridae: adventures in molecular virology
The work presented here encompasses two avenues of investigation: the first, regarding the identification of a novel retrovirus in Gunnison's prairie dogs, and the second regarding the role of cyclin-dependent kinases 8 ... -
Quantifying proximity, confinement, and interventions in disease outbreaks: a decision support framework for air-transported pathogens
The inability to communicate how infectious diseases are transmitted in human environments has triggered avoidance of interactions during the COVID-19 pandemic. We define a metric, Effective ReBreathed Volume (ERBV), that ... -
Metformin: a tool to better understand T cell mediated protection against Mycobacterium tuberculosis
To view the abstract, please see the full text of the document. -
Exploration of the arthropod virome, its biological impacts on host health, and its potential implementation in biocontrol
With the advent of next generation sequencing, viruses are being discovered at an unprecedented rate. The collection of these viruses, known as the virome, and their impact on the host is relatively understudied compared ... -
Inactivation of Mycobacterium tuberculosis for safe use outside of the BSL-3 laboratory
Techniques for pathogen inactivation have been long employed by research laboratories to help ease the financial, physical, and health strains associated with (A)BSL-3 work. While robust protocols exist for many of these ... -
Data associated with "Interpersonal relationships drive successful team science: an exemplary case-based study"
Team science, or collaborations between groups of scientists with varying expertise, is required for researching solutions to complex problems of the 21st century. Despite the essential need for such transdisciplinary ... -
Eukaryotic microbiology
This chapter details cell-cell communication highlighting studies performed in the model organism Dictyostelium discoideum. Topics covered include signaling molecules, cell surface receptors, and subversion of host cell ... -
Mycobacterium tuberculosis – mediated modulation of host macrophage metabolism in the granuloma microenvironment
Mycobacterium tuberculosis (Mtb) is the leading cause of death by an infectious agent, and tuberculosis (TB) disease continues to be a prominent global health concern. Infection with Mtb incites granulomatous inflammation, ... -
Targeting protein kinase C in an autoimmune diabetes mouse model
Protein kinase C, a family of intracellular signal transducing proteins, are critical for a myriad of cellular actions with implications in both diabetes and its complications. The isoform PKCθ is enriched in T lymphocytes ... -
Evaluation of acupuncture as an alternative therapy in a rodent model of spontaneous osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease affecting nearly 250 million people globally. With clinical signs of severe and persistent joint pain, OA is a leading cause of physical disability throughout the world. ...
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