Microbiology, Immunology, and Pathology
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Characterization of changes in metabolic pathways during dengue virus serotype 2 infection of the Aedes aegypti mosquito vector to identify control points for interrupting virus transmission
Dengue viruses (DENV) are mosquito-borne viruses that cause a wide range of acute symptoms from mild fever to lethal dengue shock syndrome in humans. DENV are transmitted primarily by Aedes aegypti (Ae. aegypti). These ... -
Flavivirus control of lipid metabolism : implications for virion formation, function and pathogenesis
Dengue viruses (DENV) are the most aggressive arthropod-born viruses worldwide with no currently available antivirals. There is a clear need to understand host viral interactions that can be exploited for therapeutic ... -
Innate and adaptive immune responses after bovine viral diarrhea virus infection in the fetal thymus
Bovine viral diarrhea virus (BVDV) infection of bovine fetuses in the first 125 days of pregnancy results in persistently infected (PI) cattle and transiently infected (TI) cattle become infected, but have a developed ... -
Cleavage of exosomal-associated transferrin receptor in dogs, cats, and horses : progress towards a soluble transferrin receptor assay
Iron deficiency anemia and anemia of chronic disease are two complications that patients in human medicine as well as veterinary medicine often encounter. These two diseases usually occur secondary to other primary diseases ... -
Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos
Mycobacterium leprae (M. leprae) is a human pathogen and the causative agent for leprosy, a chronic disease characterized by lesions of the skin and peripheral nerve damage. Zoonotic transmission of M. leprae to humans by ... -
Ivermectin-treated bird feed to control West Nile virus transmission
West Nile virus is the leading cause of arboviral fever and encephalitis in the United States. The highest WNV disease incidence occurs along the Great Plains region of the United States, as the ecology and land use provide ... -
Role of prion protein glycosylation in prion propagation, The
Transmissible Spongiform Encephalopathies (TSEs) are a group of neurodegenerative diseases that affect humans and animals alike. TSEs are caused by the accumulation of a disease producing isoform referred to as PrPSc that ... -
Bats as reservoir hosts : exploring novel viruses in New World bats
To view the abstract, please see the full text of the document. -
Applications of feline immunodeficiency virus as a model to study HIV pathogenesis
Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, and produces progressive immune depletion that eventually results in an acquired immunodeficiency ... -
Exosomes : a potential novel source of biomarkers for Tuberculosis
To view the abstract, please see the full text of the document. -
Binding of MBNL1 to CUG repeats slows 5'-to-3' RNA decay by XRN2 in a cell culture model of type I myotonic dystrophy
Type I myotonic dystrophy (DM1) is a multi-systemic inherited disease caused by expanded CTG repeats within the 3' UTR of the dystrophia myotonica protein kinase (DMPK) gene. The encoded CUG repeat-containing mRNAs are ... -
Crossing the blood-brain barrier : siRNA treatment for prion diseases
Protein misfolding diseases such as prion diseases, Alzheimer's disease, and Parkinson's disease, are fatal neurodegenerative diseases caused by a misfolded protein. There are no known therapeutics that extend survival ... -
Longitudinal characterization of peripheral prion pathogeneis in Syrian hamsters experimentally inoculated with hamster-adapted Transmissible Mink Encephalopathy
Transmissible Spongiform Encephalopathies (TSEs) are a group of infectious, neurodegenerative diseases affecting animals, including humans. Caused by misfolded proteins called prions, TSEs are characterized by a long, ... -
Mexican mosquitoes : overcoming barriers for dengue and Zika virus infection
The mosquito transmitted arboviruses cause an important burden of disease worldwide. In Latin America dengue disease is endemic with more than 1 million dengue fever cases reported yearly. In addition to dengue, chikungunya ... -
Changes in autoreactive B cell lifestyle early in development of autoimmunity
Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells, leading to decreased production of insulin and hyperglycemia. Although environmental factors contribute, genetic ... -
Pathogenesis of oral FIV infection
Feline immunodeficiency virus (FIV) is the feline analogue of human immunodeficiency virus (HIV) and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While ... -
Ecology and epidemiology of Japanese encephalitis virus in Nepal, and dynamics of infection with the virus in birds and mosquitoes
Japanese encephalitis virus (JEV) infection is common in humans and other animals in Asia, including Nepal. Morbidity and mortality due to JEV infection are higher in children than adults, although all age groups of people ... -
Potentiation of beta-lactam antibiotics against Mycobacterium tuberculosis by 2-aminoimidazoles : investigation into the mechanism of action and its relevance to mycobacterial bioenergetics
Tuberculosis, caused by Mycobacterium (M.) tuberculosis, is a global health problem still causing morbidity and mortality due in part to the emergence of drug-resistance and the lack of new antimicrobial agents to treat ... -
Enhancing the use of mosquitoes in disease surveillance through spatially explicit entomological risk indices and the validation of Xenosurveillance
To view the abstract, please see the full text of the document. -
Pharmacological characterization of losartan as a CCR2 antagonist and pre-clinical and pharmacodynamic assessment as a potential anti-metastatic therapy
To view the abstract, please see the full text of the document.
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