Department of Microbiology, Immunology, and Pathology
These digital collections include theses, dissertations, faculty publications, and datasets from the Department of Microbiology, Immunology, and Pathology. Due to departmental name changes, materials from the following historical departments are also included here: Microbiology.
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Microglial innate and adaptive immune function modulates disease pathology in and environmental pesticide model of Parkinson's disease
Parkinson's Disease (PD) is the world's foremost movement disorder with pathological features including loss of dopaminergic neurons (DAn) within the substantia nigra pars compacta (SNpc), chronic activation of glial cells, ... -
Reframing viral infections as acute metabolic disorders: dengue viruses and their dependency on host metabolic pathways
Dengue viruses (DENVs) are the etiological agent of the world's most aggressive arthropod-borne disease. At present, there are no available antivirals against DENVs. This fact underscores a dire need to examine host-virus ... -
Development of an ultrasensitive ELISA for the detection of Mycobacterium tuberculosis antigens: an impossible challenge or a promising feat?
Tuberculosis (TB) has been classically characterized as a two-state disease with active and latent phases. Latent TB infection (LTBI) is diagnosed by either the tuberculin skin test (TST) or the Interferon Gamma Release ... -
Optimization of overhead enclosure monitoring software in a rodent model of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by pain, inflammation, and decreased range of motion, leading to impaired activities of daily living and reduced quality of life. OA affects between 250 and ... -
Investigation of RelBE1 toxin-antitoxin function in the carbon-dependent metabolic adaptation of Mycobacterium tuberculosis
Tuberculosis (TB) is a devastating disease with suboptimal treatment regimens and a single vaccine with variable efficacy. Reducing the global burden of TB requires a refined arsenal of methods to prevent and treat the ... -
Noncytopathic type 2 bovine viral diarrhea virus 96B2222 induces upregulation of type-I interferon and chemokine receptor 4 expression in bovine peripheral blood mononuclear cells during in vitro infection
Bovine viral diarrhea virus (BVDV) infection leads to monetary losses in cattle operations due to morbidity and impaired growth. IT is not currently possible to identify pregnant cattle carrying fetuses persistently infected ... -
Tracking infectious prions in the body fluids of deer infected with chronic wasting disease
Chronic wasting disease (CWD) is a prion disease of cervid (elk, moose and deer) with unusually high transmission efficiency. While the nidus of disease was described in a captive herd of cervid in northern Colorado/southeastern ... -
Small RNAs in Aedes aegypti: one giant step for virus control in mosquitoes
Aedes aegypti mosquitoes are key vectors of medically relevant arthropod-borne (arbo) viruses such as Zika (ZIKV), dengue (DENV1-4), and yellow fever (YFV). When Ae. aegypti become infected with arboviruses, RNA interference ... -
Enrichment and separation of Mycobacterium tuberculosis extracellular vesicles with a side of biosafety and biosecurity
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the world's deadliest pathogens. Recently, TB fell from the leading infectious cause of death to the second leading infectious killer ... -
Characterization, quantification, and behavior of neoplastic monoclonal gammopathies in dogs and cats
Monoclonal immunoglobulin (M-protein) production can occur in a number of myeloma related diseases (MRD) in domestic animals, including multiple myeloma (MM), extramedullary plasmacytomas, solitary osseous plasmacytoma, ... -
Sindbis virus usurps the cellular HUR protein to stabilize its transcripts and promote infections of mammalian and mosquito cells
Members of the genus Alphavirus are recognized as significant human pathogens. Infection of vertebrate hosts often results in febrile illness and occasionally severe encephalitis. The archetypical alphavirus is Sindbis ... -
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus
A search for alternative Mycobacterium abscessus treatments led to our interest in the two-component regulator DosRS, which, in Mycobacterium tuberculosis, is required for the bacterium to establish a state of nonreplicating, ... -
Molecular epidemiology of leprosy: an update
Molecular epidemiology investigations are notoriously challenging in the leprosy field mainly because the inherent characteristics of the disease as well as its yet uncultivated causative agents, Mycobacterium leprae and ... -
Defining interactions between Mycobacterium leprae and Langerhans cells
Leprosy is a chronic infection that affects the skin and peripheral nerves. Written accounts of the disease date back to at least 600 BC. Mycobacterium leprae, the causative agent of leprosy was first discovered by Dr. ... -
Microbes in the mucosa: impacts of the mucosal immune system and oral vaccination with Lactobacillus acidophilus on the gut microbiome
The mucosal immune system is constantly balancing between the clearance of pathogens, tolerance of self-antigen and food, and maintenance of homeostasis within the microbiota. Vaccination via mucosal routes is advantageous ... -
Computational tools to identify correlates of vaccine-induced protection against tuberculosis
Tuberculosis is a significant threat to human health. While the BCG vaccine exists to protect children from disseminated forms of tuberculosis, it fails to protect against pulmonary tuberculosis. Thus, a better vaccine is ... -
Assessment of anopheles vectorial capacity metrics and malaria transmission factors within the Rimdamal II Study
To view the abstract, please see the full text of the document. -
Illustrating the post-introduction ecology of Rift Valley fever virus in the United States of America
Rapid urbanization, increasing international travel, and our changing climate are modifying the existing interspecies interactions at the interfaces between human, wildlife, and livestock interfaces, increasing the potential ... -
From BCG vaccination routes to lung and gut microbiota: avenues to tackle Mycobacterium tuberculosis infection
Tuberculosis is an infectious lung disease responsible for approximately 1.4 million human deaths, world-wide every year. The causal agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), has been estimated ... -
Chronic wasting disease strain diversity, distribution and transmission
Chronic wasting disease (CWD) is an invariably fatal prion disease affecting captive and free-ranging cervids, including white-tailed deer, mule deer, moose, elk and reindeer. Since the initial discovery of the disease in ...
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