Department of Microbiology, Immunology, and Pathology
These digital collections include theses, dissertations, faculty publications, and datasets from the Department of Microbiology, Immunology, and Pathology. Due to departmental name changes, materials from the following historical departments are also included here: Microbiology.
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Eukaryotic microbiology
This chapter details cell-cell communication highlighting studies performed in the model organism Dictyostelium discoideum. Topics covered include signaling molecules, cell surface receptors, and subversion of host cell ... -
Mycobacterium tuberculosis – mediated modulation of host macrophage metabolism in the granuloma microenvironment
Mycobacterium tuberculosis (Mtb) is the leading cause of death by an infectious agent, and tuberculosis (TB) disease continues to be a prominent global health concern. Infection with Mtb incites granulomatous inflammation, ... -
Targeting protein kinase C in an autoimmune diabetes mouse model
Protein kinase C, a family of intracellular signal transducing proteins, are critical for a myriad of cellular actions with implications in both diabetes and its complications. The isoform PKCθ is enriched in T lymphocytes ... -
Evaluation of acupuncture as an alternative therapy in a rodent model of spontaneous osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease affecting nearly 250 million people globally. With clinical signs of severe and persistent joint pain, OA is a leading cause of physical disability throughout the world. ... -
Clinical and molecular characterization of canine small cell B-cell lymphocytosis disorders
To view the abstract, please see the full text of the document. -
Molecular characterization of canine peripheral T-cell lymphoma
To view the abstract, please see the full text of the document. -
Extrinsic incubation temperature impacts on Zika virus evolution and vector competence during systemic Aedes infection
Arthropod-borne viruses (arboviruses) are distinctive in that they are required to constantly replicate in different hosts and in a wide range of temperatures for their perpetuation in nature. Vertebrate hosts tend to ... -
Development of Lactobacillus acidophilus as an oral vaccine vector and effects of rice bran ingestion on the mucosal health of Malian infants
Most pathogens enter the body at the mucosa and induce innate and adaptive immune responses at these surfaces essential for protection against infection and disease. Induction of mucosal immune responses is best achieved ... -
Medical and molecular virology
This book was created for upper division microbiology students studying virology. It will describe the molecular biology and major diseases of virus families that cause significant disease in animals and humans. This book ... -
Immune modulatory and antimicrobial properties of mesenchymal stromal cells delivered systemically
To view the abstract, please see the full text of the document. -
Molecular characterization of novel transcription of antisense toxin-antitoxin RNA in regulating Mycobacterium tuberculosis
Despite more than seventy years of available anti-tuberculosis (TB) treatments, Mycobacterium tuberculosis (Mtb) remains the deadliest human pathogen. Novel short-course therapies are needed that effectively treat latent ... -
Targeted computational analysis of the C3HEB/FEJ mouse model for drug efficacy testing
Efforts to develop effective and safe drugs for the treatment of tuberculosis (TB) require preclinical evaluation in animal models. Alongside efficacy testing of novel therapies, effects on pulmonary pathology and disease ... -
Permethrin resistance status and associated mechanisms in Aedes albopictus mosquitoes: implications for vector control
There are major public health concerns regarding the spread of mosquito-borne diseases such as dengue, Zika, and chikungunya. The primary method to reduce the spread of these diseases is by killing the major mosquito ... -
Understanding the process of Mycobacterium abscessus reinfection on host immunity
Mycobacterium abscessus is a bacterial pathogen emerging in humans. The bacterium is difficult to treat, and it results in increased mortality. The patient case rates of diseases associated with this bacterium are increasing. ... -
Dataset associated with “Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors”
Background: T zone lymphoma (TZL), a histologic variant of peripheral T cell lymphoma, represents about 12% of all canine lymphomas. Golden Retrievers appear predisposed, representing over 40% of TZL cases. Prior research ... -
Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection
Feline infectious peritonitis (FIP) is a disease with high mortality that results from a mutation in the genome of the relatively harmless and ubiquitous feline coronavirus (FCoV) (Licitra, Millet et al. 2013). FIP causes ... -
Comparative physiology of Mycobacterium abscessus in synthetic laboratory medium and cystic fibrosis sputum
Mycobacterium abscessus complex is a group of rapid-growing nontuberculous mycobacteria that are multidrug resistant and that cause chronic pulmonary infections in individuals with cystic fibrosis (CF) and other pre-disposing ... -
Inhalational antibiotic therapy for treatment of chronic pulmonary Mycobacterium abscessus disease in mice
Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes chronic pulmonary infections. Due to M. abscessus's intrinsic antibiotic resistance, treatment is often complex with low cure rates. ... -
Epidemiological investigation of antimicrobial resistance in beef production using metagenomic sequencing
Globally, the emergence of antimicrobial resistance (AMR) resulting in treatment failure is recognized as a growing public health threat. Antimicrobial use practices used in beef production are thought to be a direct driver ... -
Characterizing the genetic evolution of endemic bluetongue virus strains
Bluetongue virus is an arthropod-borne virus that can cause severe disease in susceptible animals. Transmitted by biting midges in the genus Culicoides, the bluetongue virus particle (genus Orbivirus, family Reoviridae) ...
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