Department of Microbiology, Immunology, and Pathology
These digital collections include theses, dissertations, and faculty publications from the Department of Microbiology, Immunology, and Pathology. Due to departmental name changes, materials from the following historical departments are also included here: Microbiology.
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Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection
Feline infectious peritonitis (FIP) is a disease with high mortality that results from a mutation in the genome of the relatively harmless and ubiquitous feline coronavirus (FCoV) (Licitra, Millet et al. 2013). FIP causes ... -
Comparative physiology of Mycobacterium abscessus in synthetic laboratory medium and cystic fibrosis sputum
Mycobacterium abscessus complex is a group of rapid-growing nontuberculous mycobacteria that are multidrug resistant and that cause chronic pulmonary infections in individuals with cystic fibrosis (CF) and other pre-disposing ... -
Inhalational antibiotic therapy for treatment of chronic pulmonary Mycobacterium abscessus disease in mice
Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes chronic pulmonary infections. Due to M. abscessus's intrinsic antibiotic resistance, treatment is often complex with low cure rates. ... -
Epidemiological investigation of antimicrobial resistance in beef production using metagenomic sequencing
Globally, the emergence of antimicrobial resistance (AMR) resulting in treatment failure is recognized as a growing public health threat. Antimicrobial use practices used in beef production are thought to be a direct driver ... -
Characterizing the genetic evolution of endemic bluetongue virus strains
Bluetongue virus is an arthropod-borne virus that can cause severe disease in susceptible animals. Transmitted by biting midges in the genus Culicoides, the bluetongue virus particle (genus Orbivirus, family Reoviridae) ... -
Biofilm dynamics and the response to N-oxides in Burkholderia pseudomallei
Burkholderia pseudomallei is a saprophytic bacterium inhabiting wet soils in tropical regions and is the causative agent of melioidosis, an emerging infectious disease of high mortality. Although the incidence of melioidosis ... -
Use of metagenomic sequencing as a tool for pathogen discovery with further investigation of novel reptilian serpentoviruses, The
To view the abstract, please see the full text of the document. -
Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
Endogenous retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they ... -
MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria, The
Integral membrane transporters of the Mycobacterial Membrane Protein Large (MmpL) family and their interactome play important roles in the synthesis and export of mycobacterial outer membrane lipids. Despite the current ... -
Pathogenesis and immunological response of Yersina pestis in carnivores
Yersinia pestis is the causative agent of plague. The pathogen is endemic in rodent populations in the western United States where humans and other mammals become infected with this highly virulent organism when exposed ... -
Evolution of mutations associated with pyrethroid resistance and the reversal of resistance in Aedes aegypti
Worldwide vector control has been relying heavily on pyrethroid insecticides to reduce Aedes aegypti Linnaeus populations. Pyrethroids are relatively inexpensive, have low vertebrate toxicity, and have been efficient in ... -
Understanding Mycobacterium abscessus in cystic fibrosis mice
Cystic fibrosis (CF) is caused by mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which normally encodes an ABC transporter-class ion channel protein that allows chloride and thiocyanate ... -
Female- and intruder-induced ultrasonic vocalizations as proxy indicators for animal well-being and postoperative pain recognition in C57BL/6J mice
Mice are the most commonly used research animal and often undergo painful procedures. It is important to minimize pain and distress in research animals. However, recognizing pain and distress in mice is challenging. There ... -
Feline foamy virus in domestic cats: use as a vaccine vector, characterization of infection, and association with other diseases
Foamy viruses (FVs) are retroviruses from the Spumaretrovirinae subfamily. FVs are globally prevalent retroviruses with a unique molecular biology. FVs establish apparently apathogenic lifelong infections. Due to this, FVs ... -
Extrinsic and intrinsic drivers of feline immunodeficiency virus evolution in the mountain lion
Viruses are among the most rapidly evolving entities in biology and are so intricately associated with their obligate hosts that the boundary between host and pathogen, and thus the study of one versus the other, is blurred ... -
T zone lymphoma: cellular origin and function
The lymphoid system is exceedingly complex with specialized subsets of lymphocytes involved in both the innate and adaptive immune response. Lymphocytes are subdivided into T cells and B cells with lymphoproliferative ... -
Exploration of viral RNA-mediated strategies to stall and repress the cellular exoribonuclease XRN1, An
The regulation of mRNA decay plays a vital role in determining both the level and quality control of cellular gene expression in eukaryotes. Since they are likely recognized as foreign/unwanted transcripts, viral RNAs must ... -
Roles of iron, the infrapatellar fat pad, and dietary factors in the Hartley guinea pig model of spontaneous osteoarthritis, The
Osteoarthritis (OA) is the most prevalent musculoskeletal disorder across the world, affecting close to 300 million people. The disease manifests as degeneration and loss of articular cartilage, synovial hyperplasia, ... -
Characterization of changes in metabolic pathways during dengue virus serotype 2 infection of the Aedes aegypti mosquito vector to identify control points for interrupting virus transmission
Dengue viruses (DENV) are mosquito-borne viruses that cause a wide range of acute symptoms from mild fever to lethal dengue shock syndrome in humans. DENV are transmitted primarily by Aedes aegypti (Ae. aegypti). These ... -
Flavivirus control of lipid metabolism: implications for virion formation, function and pathogenesis
Dengue viruses (DENV) are the most aggressive arthropod-born viruses worldwide with no currently available antivirals. There is a clear need to understand host viral interactions that can be exploited for therapeutic ...
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