Theses and Dissertations - Department of Biomedical Sciences
Recent Submissions
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Molecular consequences of fetal BVDV persistent infection: tales from the placenta and spleen
To view the abstract, please see the full text of the document. -
Super-resolution imaging reveals mechanisms of glutamate transporter localization near neuron-astrocyte contacts
Astrocytes contact neurons at several locations, including somatic clusters of Kv2.1 potassium channels and synapses across the brain. A primary function of astrocytes at these locations is to limit the action of extracellular ... -
Anatomic plasticity and functional impacts of neural – immune and neural – epithelial signaling in the intestine
The intestinal wall is a multicompartmental barrier tissue composed of over 25 distinct cell types with integrated and complex signaling both within and between compartments. The gut wall is also a large endocrine organ ... -
Angiotensin-II signaling in the pars reticulata GABA-ergic neurons in the substantia nigra and its implications in nigral neurotransmission
Renin-Angiotensin-system is one of the most widely studied hormonal systems in the peripheral system and is primarily associated with the essential function of regulating blood pressure, fluid and electrolyte balance in ... -
Evaluating curricular implementation techniques to enhance anatomy education
The need for healthcare workers in the United States is growing exponentially, and in order to meet this increasing demand, medical schools and other health-related institutions have begun to increase their student enrollment. ... -
Na+ -activated K+ channels protect against overexcitation and seizure-like behavior in Drosophila
Na+-activated K+ channels (KNa) encode K+ channels that are activated by internal Na+ and are widely expressed throughout the mammalian central nervous system. Based on the biophysical properties of the channels, it has ... -
Cholinergic synaptic homeostasis is regulated by Drosophila α7 nicotinic acetylcholine receptors and Kv4 potassium channels
Homeostatic synaptic plasticity (HSP) is an important mechanism that stabilizes neural activity during changes that occur during development and learning and memory formation, and some pathological conditions. HSP in ... -
Influence of FADS2 expression on cardiovascular risk: role of mitochondrial arachidonic acid
Long-chain polyunsaturated fatty acids (LC-PUFA) are widely believed to influence cardiovascular health and disease in humans and can be supplied through the diet or endogenously synthesized from the essential PUFAs linoleic ... -
Electrophysiological analysis of Kv2 channel regulation by non-canonical and canonical mechanisms
Kv2 channels are the most abundant voltage-gated potassium channels in the mammalian nervous system and entire body. These channels regulate action potential firing and apoptosis via their canonical conducting functions. ... -
Localization of nerve growth factor-β in the stallion reproductive tract
Nerve growth factor-β (NGF-β) is a protein produced in the reproductive tract of camelids (camels, llamas, and alpacas) that has been identified as the ovulation inducing factor in seminal plasma. NGF-β from seminal plasma ... -
Use of fecal and serum estradiol analysis for estimation of pregnancy status in the mare
Overabundant feral horse populations within the United States cause significant and detrimental economic and ecological impacts. Aside from helicopter roundups and long-term holding facilities, current management practices ... -
L-type calcium channel-dependent signaling impacts GnRH receptor function and intercellular communication in cultured gonadotropes
The hypothalamic-pituitary-gonadal (HPG) axis is a negative feedback biological system critical in fertility, reproduction and development. Gonadotropin-releasing hormone (GnRH) is first released by the hypothalamus and ... -
Reevaluating the functional role of the C₂A domain of synaptotagmin in neurotransmitter release
Efficient cell-to-cell communication is critical for nervous system function. Fast, synchronous neurotransmission underlies this communication. Following depolarization of the nerve terminal, Ca2+ enters the presynaptic ... -
Gene regulation by let-7 microRNAs during human and sheep placental development
Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality and affects more than 30 million infants every year across the world. Its occurrence is 5–15% of all pregnancies in the United ... -
Impact of equine sperm phospholipase C zeta content and sperm tail components on cleavage rates after intracytoplasmic sperm injections of equine and bovine oocytes
Intracytoplasmic sperm injection (ICSI) is used in equine assisted reproductive medicine to generate offspring when other procedures fail. However, for some stallions, ICSI is not successful in producing embryos. This could ... -
Sex-dependent function and regulation of the hypothalamic pituitary adrenal axis
Physiological responses to stressors are largely governed by a neuroendocrine axis, the hypothalamic pituitary adrenal (HPA) axis. Whereas HPA activation is necessary for body wide adaptation to a stressor via the production ... -
Molecular mechanisms regulating Kv2.1-induction of endoplasmic reticulum / plasma membrane contact sites
Kv2 voltage gated potassium channels localize to 'clusters' on the soma, axon initial segment, and dendritic arbor of hippocampal neurons. For decades the molecular mechanism behind this localization pattern was unknown. ... -
Age-dependent decline in Kv4 channels, underlying molecular mechanisms, and potential consequences for coordinated motor function
The voltage-gated potassium channel, Kv4, is widely expressed in the central nervous system and it is responsible for a highly conserved rapidly inactivating A-type K+ current. Kv4 channels play a role in the regulation ... -
Genomic and non-genomic androgen signaling in human placenta cells
To view the abstract, please see the full text of the document. -
Oncofetal proteins regulate proliferation and differentiation in placental cells
The chromatin associated transcription factor HMGA2 is a downstream target of let-7 miRNAs and binds to chromatin to regulate gene expression, inducing rapid cell proliferation during embryogenesis. Inhibition of let-7 ...
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