Theses and Dissertations - Department of Biomedical Sciences
Recent Submissions
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Association of oocyte and early embryo morphology with age and the establishment and maintenance of pregnancy after ICSI in mares
Increasing maternal age in humans, horses and lab animals has been associated with a decrease in fertility. Oocyte quality and morphology have been implicated as primary causes of reduced fertility in older mares. Selected ... -
Glucocorticoid-dependent regulation of molecular clocks and dendritic spines in the ventromedial prefrontal cortex
Biological rhythms in the brain and periphery are governed by the suprachiasmatic nucleus of the hypothalamus (SCN) and the SCN's control of rhythmic adrenal glucocorticoid (GC) secretions via the hypothalamic pituitary ... -
Evaluation of kisspeptin in the mare
Identified in 2003 for their role in reproductive physiology, kisspeptins have become major players in the field of reproductive neuroendocrinology. With the ability to act as a central regulator for the onset of reproductive ... -
Optimizing storage of bovine sperm between semen collection and sexing
To view the abstract, please see the full text of the document. -
Characterization of selected gene expression patterns as potential markers for oocyte quality in young versus old mares
As a female ages a series of alterations in normal physiology take place, during this process fecundity decreases. The reproductive system starts to shut down as a consequence of hormonal, histological and anatomical ... -
Cryopreservation of cooled semen for equine intracytoplasmic sperm injection
The development of intracytoplasmic sperm injection (ICSI) for use in the horse has resulted in unique needs for semen. Modifications of ways to handle sperm for ICSI-related procedures were investigated through a series ... -
In vitro capacitation of stallion spermatozoa
Equine in vitro fertilization has resulted in limited success, and progress is hindered due to a lack of understanding the molecular and biochemical events involved in stallion sperm capacitation. As no single test exists ... -
Sexual divergence in prefrontal neural regulation and encoding of depression-associated behaviors
Major depressive disorder (MDD) accounts for the most years lived with disability worldwide. Yet, despite its staggering prevalence, the biological mechanisms underpinning MDD onset are not understood, further complicated ... -
Reactive oxygen species regulate activity-dependent transport and delivery of AMPA receptors to synapses
In neurons, changes in the subcellular localization of the AMPA subtype of ionotropic glutamate receptors (AMPARs) is necessary for learning and memory. AMPARs are primarily translated in the cell body and transported ... -
Investigation of assisted reproductive technologies (ART) for conservation of Bovidae
There is an ongoing loss in global biodiversity in both wildlife and domestic species, creating a need to protect and preserve valuable genetics for the maintenance and sustainability of these populations. One of the ... -
Glucocorticoid receptor signaling is required for acclimation of skeletal muscle to hypobaric hypoxia
Hypobaric hypoxia (HH) encountered at high altitudes acutely impairs aerobic exercise capacity, which partially recovers following 1-2 weeks of acclimation to chronic HH. Persistent elevations in serum glucocorticoids ... -
Integration and evaluation of virtual reality in distance medical education
The need for distance education is ever increasing, and it is therefore essential to continue advancing distanced pedagogical techniques to provide exceptional and equitable education to students. Previous studies suggest ... -
Impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep, The
Glucose is the primary energy substrate for fetal oxidative processes and growth. In order for glucose to be transported from maternal to fetal circulation in the ruminant placenta, it must be sequentially transported by ... -
Translocation of insulin receptors into plasma membrane microdomains in response to insulin and to insulin-enhancing vanadium and chromium compounds
We have examined the translocation of insulin receptors into specialized, cholesterol-enriched membrane microdomains called lipid rafts following treatment of RBL-2H3 cells with insulin, bis-maltolatooxovanadium (BMOV) and ... -
Interaction of [VO₂(MA)₂]⁻ with model membranes: relevance to insulin enhancing effects of BMOV and its oxidized form
Anti-diabetic vanadium-containing compounds and salts reportedly have effects on the overall organization of the cytoskeleton and the plasma membrane of cells. For ligand-mediated signaling, appropriate cytoskeletal and ... -
Regulation of trophoblast stem cell maintenance and differentiation by LIN28 and AP-2γ
The placenta is a unique organ essential for survival of the fetus in all eutherian mammals. Failure to develop a normal placenta in humans can lead to diseases, such as pre-eclampsia, with high morbidity and mortality for ... -
Estradiol exposure alters gonadothropin-releasing hormone (GNRH) induced gonadotrope plasticity
The reproductive axis is dependent upon communication among the hypothalamus, pituitary and gonads. For successful ovulation, a large increase in circulating estradiol provides positive feedback at both the hypothalamic ... -
Luteinizing hormone induced oocyte maturation initiates mRNA decay in cattle
Oocyte maturation is a complex process consisting of signal transduction, ultrastructural changes, and mRNA transcription, translation, storage, and degradation. In vitro-matured oocytes initiate maturation in response to ... -
Membrane organization of luteinizing hormone receptors during signal transduction
Mechanisms involved in signal transduction by luteinizing hormone (LH) receptors are important for regulating key events in mammalian reproduction, such as ovulation, sex hormone production and maintenance of pregnancy. ... -
Proopiomelanocortin neuron manipulation in mouse models of energy balance disorders
Proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are critical regulators of energy balance. Highly conserved amongst mammalian species, POMC neurons release peptide transmitters to help ...
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