Recent Submissions

  • Clinical importance of autophagy dependency and inhibition in cancer treatment 

    Author(s):Van Eaton, Kristen M.
    Date Issued:2021
    Format:born digital; doctoral dissertations
    Autophagy, a lysosomal degradation recycling process, has a complex and context-dependent role in cancer. Certain cancers have been found to be inherently dependent on autophagy for survival regardless of the environment. ...
  • Molecular diagnostic platforms for point-of-need pathogen detection 

    Author(s):Jain, Sidhartha
    Date Issued:2021
    Format:born digital; doctoral dissertations
    Rapid, accurate, reliable nucleic acid testing (NAT) platforms are essential in the diagnosis and management of diseases. The inherent complexity associated with NAT requires that such testing be performed in centralized ...
  • Biomimetic and antimicrobial surfaces for orthopedic implants 

    Author(s):Wigmosta, Tara
    Date Issued:2021
    Format:born digital; doctoral dissertations
    The number of total knee and hip replacement surgeries is expected to continue to rise in the United States. As such, the number of revision surgeries is also expected to rise. The two most common causes of failure for ...
  • Pharmacokinetic investigation of chloroquine analogues in cancer autophagy modulation, A 

    Author(s):Collins, Keagan P.
    Date Issued:2020
    Format:born digital; doctoral dissertations
    Hydroxychloroquine (HCQ) is currently being investigated for safety and efficacy as an autophagy inhibitor in Phase I/II cancer clinical trials. It is the only clinically-approved autophagy inhibitor for use in cancer ...
  • Computational approaches to predict drug response to cytotoxic chemotherapy 

    Author(s):Mannheimer, Joshua D.
    Date Issued:2020
    Format:born digital; doctoral dissertations
    Cancer is the second leading cause of death in the United States. Statistically, within a lifetime there is slightly above a one-third chance of developing some form of cancer and a one in five chance of dying from the ...
  • Atomic force microscopy: more than surface imaging 

    Author(s):Bishop, Terrance Tyler
    Date Issued:2020
    Format:born digital; masters theses
    Atomic Force Microscopy (AFM) is a powerful imaging tool that has capabilities that go beyond the abilities of most other microscopes. Here, three examples of these capabilities were considered. First, the AFM was operated ...
  • Design and evaluation of an instrumented microfluidic organotypic device and sensor module for organ-on-a-chip applications 

    Author(s):Richardson, Alec Evan
    Date Issued:2020
    Format:born digital; masters theses
    Organ and tissue-on-a-chip technologies are powerful tools for drug discovery and disease modeling, yet many of these systems rely heavily on in vitro cell culture to create reductionist models of tissues and organs. ...
  • Nitric oxide-releasing or generating surfaces for blood-contacting medical devices 

    Author(s):Zang, Yanyi
    Date Issued:2020
    Format:born digital; doctoral dissertations
    Medical device-induced thrombosis is a major complication that impairs the expected performance of blood-contacting medical devices. Traditional anticoagulation therapies are used to reduce thrombus formation; however, ...
  • Fabrication of natural and magnetic slippery surfaces 

    Author(s):Sutherland, Daniel James
    Date Issued:2019
    Format:born digital; masters theses
    Liquid-infused porous surfaces (LIPS) are a type of low adhesion surfaces. They allow most common solids and liquids to slide off the surface easily. Because of this they are able to reduce the adhesion of food, ice, and ...
  • Development of hyaluronan enhanced expanded polytetrafluoroethylene and linear low density polyethylene for blood contacting applications, The 

    Author(s):Bui, Hieu T.
    Date Issued:2019
    Format:born digital; doctoral dissertations
    Cardiovascular disease is the number one cause of death in high income, industrialized countries. Designing cardiovascular implants from synthetic polymers is a cost-effective solution to the growing demand for medical ...
  • Kinetics of proteins on lipid bilayers, The 

    Author(s):Nepal, Kanti
    Date Issued:2017
    Format:born digital; masters theses
    Signaling molecules trigger downstream signaling pathways when they arrive at the plasma membrane. They have to be recruited to the plasma membrane by membrane targeting domains. Our experiments throughout focus on ...
  • Constitutive modeling of the biaxial mechanics of brain white matter 

    Author(s):Labus, Kevin M.
    Date Issued:2016
    Format:born digital; doctoral dissertations
    It is important to characterize the mechanical behavior of brain tissue to aid in the computational models used for simulated neurosurgery. Due to its anisotropy, it is of particular interest to develop constitutive models ...
  • Influence of adipose-derived mesenchymal stromal cells on osteosarcoma minimal residual disease 

    Author(s):Aanstoos-Ewen, Megan
    Date Issued:2015
    Format:born digital; doctoral dissertations
    Introduction: Mesenchymal stromal cells (MSCs) have been shown to improve bone integration and healing in several preclinical studies and have therapeutic potential in limb salvage following massive bone loss due to tumor ...
  • Haversian bone model of fracture healing in a simulated microgravity environment, A 

    Author(s):Gadomski, Benjamin C.
    Date Issued:2015
    Format:born digital; doctoral dissertations
    Ground-based models of weightlessness and microgravity have provided valuable insights into how dynamic physiological systems adapt or react to reduced loading. Almost all of these models have used rodent hindlimb unloading ...
  • Effects of walking speed on knee joint loading estimated via musculoskeletal modeling 

    Author(s):Haight, Derek Joseph
    Date Issued:2012
    Format:born digital; masters theses
    Walking is the most common form of physical activity and is assumed to incur a relatively small risk of musculoskeletal injury. However, walking related- musculoskeletal injuries, particularly at the knee joint, are not ...
  • Titania nanotube arrays: interfaces for implantable devices 

    Author(s):Smith, Barbara Symie
    Date Issued:2012
    Format:born digital; doctoral dissertations
    For the 8-10% of Americans (20-25 million people) that have implanted biomedical devices, biomaterial failure and the need for revision surgery are critical concerns. The major causes for failure in implantable biomedical ...
  • Compartmentalization of membrane proteins by the actin cytoskeleton 

    Author(s):Higgins, Jenny
    Date Issued:2013
    Format:born digital; masters theses
    Acting as the point of contact for the outside world, the plasma membrane is crucial for cellular signaling events. Proper organization of membrane components is necessary to accomplish this task. Although a number of ...
  • Nanoparticulate-reinforced hyaluronan copolymer hydrogel for intervertebral disc repair, A 

    Author(s):Yonemura, Susan S.
    Date Issued:2011
    Format:born digital; doctoral dissertations
    Degenerative disc disease (DDD) is an inevitable consequence of aging, commonly resulting in low back pain (LBP). Current clinical treatment options for disc degeneration exist at two extremes: conservative management or ...