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Department of Clinical Sciences

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These digital collections include theses, dissertations, student publications, faculty publications, and datasets from the Department of Clinical Sciences.

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Browsing Department of Clinical Sciences by Subject "altitude"

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    Pre-weaned beef calf mortality on high altitude ranches in Colorado
    (Colorado State University. Libraries, 2013) Neary, Joseph Michael, author; Garry, Franklyn, advisor; Gould, Daniel, committee member; Knight, Anthony, committee member; Dargatz, David, committee member
    Nationwide Colorado has the 14th largest beef cow population. The sale of cattle and calves is Colorado's highest grossing agricultural product generating over $3 billion annually. Many of the 11,600 cow-calf operations are located at high elevations in the Rocky Mountains. Producer reports suggest that a large number of these ranches experience high pre-weaned calf death loss, as high as 20% of the calf crop, between branding in the spring and weaning in the autumn. During this time many cow-calf operations graze their animals on high altitude mountainous pastures. Due to the extensive, inaccessible nature of the mountainous terrain there have been limited prior investigations of the death loss problem. For the present study physiological, pathological and epidemiological investigations were performed to characterize the problem. A survey of Colorado's beef producers found that the odds of a producer having a greater than average calf death loss increased with increasing altitude. This greater death loss was mainly due to respiratory problems and pulmonary hypertension (also known as high altitude disease or brisket disease). Postmortem examination of calves revealed that approximately equal numbers of calves died from bronchopneumonia and pulmonary hypertension even on ranches that have selected for low pulmonary artery pressure herd sires for over 20 years. The postmortem lesions obtained from calves with pulmonary hypertension suggest that our current understanding of the disease is insufficient. Overlap of clinical signs makes appropriate treatment decisions by producers difficult. Typically, cases of bronchopneumonia occurred earlier in the summer grazing season than cases of pulmonary hypertension, which occurred in the late summer-early fall period. Blood biochemical values for healthy calves at altitude (9,000 ft. or 2,743 m) were strikingly different from literature reports of similarly aged calves sampled at lower altitudes. This reflects the extreme physiological challenges associated with life at high altitude. Arterial blood-gas analysis determined that calves at high altitude have lower oxygen tensions than expected despite hyperventilation. Hematocrit and hemoglobin levels were not significantly increased over age-matched calves at sea level despite chronic hypoxia. In summary, this project determined that high levels of pre-weaned calf death loss occur on high altitude cow-calf operations due to bronchopneumonia and pulmonary hypertension. Why these diseases are particularly problematic is discussed. Further studies are necessary if the problem is to be addressed.
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    Pulmonary arterial pressures, arterial blood-gas tensions, and serum biochemistry of beef calves born and raised at high altitude
    (Colorado State University. Libraries, 2013-07-15) Neary, Joseph M., author; Garry, Franklyn B., author; Holt, Timothy N., author; Knight, Anthony P., author; Gould, Daniel H., author; Dargatz, David A., author; Dove Medical Press Ltd., publisher
    High-altitude exposure is physiologically challenging. This is particularly true for animals native to low-altitude environments, such as British breeds of cattle. The objective of this study was to document the effect of high altitude on select physiological parameters of healthy beef calves (Bos taurus) born and raised on a high-altitude ranch typical of the Rocky Mountain region. Pulmonary arterial pressures, arterial blood-gas tensions, serum biochemistry, and hematocrit were evaluated. The calves studied were a composite of British (50%-75%) and Continental (25-50%) breeds born on one ranch at an altitude of 2410 m. Calves were sampled at an altitude of 2410 m when 1 month old and again at an altitude of 2730 m when 3 and 6 months old. Between 3 and 6 months of age, calves had access to grazing from 2730 m to approximately 3500 m above sea level. On each occasion, 16 to 50 calves were sampled. Only calves that remained healthy throughout all three testing periods were included in the dataset. Calves with the highest pulmonary arterial pressures at 1 month of age tended to have the highest pressures at 6 months of age (r = 0.43, P = 0.16, n = 12). Respiratory alkalosis was greatest at 6 months of age (pH 7.48 ± 0.06). Mean alveolar-arterial oxygen pressure gradients were 11.7and 11.6 mmHg at 3 and 6 months of age, indicating poor transfer of oxygen from the alveoli into the pulmonary blood. Median values for blood lactate ranged from 1.4 to 3.4 mmol/L indicating substantial anaerobic respiration at all ages. Mean hematocrits were ≤ 35.7%, only slightly higher than values obtained from age-matched calves at sea level. These results suggest that the provision of oxygen to the peripheral tissues of beef calves may be compromised at altitudes over 2410 m. This may have implications for diseases of the cardiopulmonary system.