Browsing by Author "Olson, Kenneth E., advisor"
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Item Open Access The role of midgut serine proteases in Aedes aegypti vector competence(Colorado State University. Libraries, 2007) Brackney, Douglas Eugene, author; Olson, Kenneth E., advisorNumerous gut-associated viruses utilize host proteolytic enzymes to facilitate enhancement of infection. Similarly, arboviruses infecting the invertebrate host (vector) through the alimentary tract may exploit serine proteases in the midgut to enhance vector infection. Recent genetic and biochemical experiments have demonstrated that dengue virus type 2 (DENV-2) may require proteolytic processing by midgut trypsins to efficiently infect Aedes aegypti. These results suggest midgut serine proteases may influence A. aegypti vector competence. The requirement of serine proteases in DENV-2 infection of the vector provides unique targets for development of novel control strategies through approaches such as transmission blocking vaccines.