Browsing by Author "Henao-Tamayo, Marcela I., author"
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Item Open Access Analysis of T cell subsets induced in response to Mycobacterium tuberculosis infection(Colorado State University. Libraries, 2009) Henao-Tamayo, Marcela I., author; Orme, Ian, advisorTuberculosis, an ancient disease, still kills more people each year than does any other bacterial infection. The global epidemic of tuberculosis (TB) results in eight million new tuberculosis cases per year and two million deaths; 98% of these occur in developing countries. At present the only available vaccine against tuberculosis, M. bovis Bacillus Calmette-Guerin (BCG), has proven unreliable and only minimally protects against pulmonary tuberculosis in adults. The reasons why the BCG vaccine is not fully protective are still very unclear, and even though novel vaccines are being developed, there is not a clear understanding of what kind of immune response they should elicit in order to provide maximum protection. The overall aim of these studies, therefore, was to investigate the T cell subsets generated by M. tuberculosis [including clinical strains] as well as further analysis of those generated by BCG, in order to explore their role in protection against M. tuberculosis infection.