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Browsing by Author "Carsten, Ronald E., author"

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    In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia
    (Colorado State University. Libraries, 2008) Carsten, Ronald E., author; Ullrich, Robert L., advisor
    Resveratrol has been shown to have cancer preventive properties. It modulates a wide range of molecular targets including those involved with induction of apoptosis and cell cycle arrest in a concentration dependent fashion. This study was designed to investigate resveratrol's ability to reduce radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.