Examining the Influence of Histone Chaperones on Nuclear Size
Size alterations in the nucleus have been visualized by pathologists for many years to diagnose and prognose cancer. Nuclear size and morphology aberrations are also common in numerous diseases. However, it is unknown whether altered nuclear size is the result or cause of pathogenesis. How the size of the nucleus is regulated is a fundamental cell biological question. A better understanding of the mechanisms that govern nuclear size regulation could elucidate novel therapeutics for cancer and disease. Here we review the structures that constitute the nucleus and delve into some of the mechanisms ...
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