Gonadotrope Specific Ablation of JNK 1/2 Leads to Impaired Fertility
Gonadotropin releasing hormone (GnRH) activation of gonadotrope cells initiates an intricate network of signaling pathways that results in the synthesis and secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), from the anterior pituitary. Previous work highlighted an important role for the c-Jun NH2-terminal kinase (JNK) signaling cascade in regulating GnRH receptor (GnRHR) expression levels and pulsatile secretion of LH; essential events for reproductive viability. Awaiting systematic clarification are the in vivo requirements of JNK in the regulation of ...
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