Effect of CARD9 on adipocyte lipolysis
Obesity is highly prevalent and causes diseases such as diabetes. One contributing factor is chronic inflammation. The adaptor protein caspase recruitment domain-containing protein 9 (CARD9) is involved in the innate immune response by activating pro-inflammatory cytokines in obesity. Another contributing factor is basal and stimulated lipolysis. The end product, free fatty acids, accumulate in the body and result in insulin resistance (IR) and diabetes. From our previous study, it was found that high fat diet (HFD) induces IR. A CARD9-/- animal model on HFD had improved but not completely ...
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