Profiling of expression of IL-10, IFNγ, and TNFα in the PBMCs of mice infected with S19 B. abortus suggests a basic mechanism for the murine immunological response to infection with S19
Brucellosis is an infection caused by the bacterium Brucella abortus, which is a concern for both the cattle industry and wildlife organizations. Infection is typically asymptomatic, but has been known to occasionally result in spontaneous abortions in cattle and elk. Humans have also been infected, though treatment is possible. Using the murine (mouse) model, we attempted to characterize and profile the expression of cytokines that occurs during infection with B. abortus Strain 19 (S19), currently a vaccination strain for cattle. Thirty-five mice were vaccinated with S19 and blood samples were ...
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