Gender differences in AMPK activation in the heart and white quadriceps muscle following exercise training in mice
AMP-activated protein kinase (AMPK) mediates glucose uptake through expression of GLUT-4 on cell membranes and its use as a fuel, thus preventing injury and apoptosis. Mice were randomly assigned to be trained (T), sedentary and resting (SR), or sedentary and exercised to exhaustion (SE) immediately prior to sacrifice. Samples were taken from the heart and quadriceps. Males had higher activation of AMPK among all groups in the heart. TE groups had higher activation than SR and SE. SR groups had higher activation than SE groups. In quadriceps, the females showed higher AMPK activation in the TE ...
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