Mathematical modeling of glucose and insulin dynamics in adolescent girls to quantify measures of insulin sensitivity
The regulation of plasma glucose is a key component of human metabolism and is largely regulated by insulin that facilitates glucose uptake by tissues. When tissues become more resistant to insulin, glucose concentrations remain elevated longer and more insulin is required to elicit the same physiologic response. Insulin resistance (IR) is a crucial element of the pathology of the metabolic syndrome, which includes increased risk of stroke, heart disease, type 2 diabetes mellitus, and nonalcoholic fatty liver disease (NAFLD). Decreased insulin sensitivity (SI) is associated with pubertal changes, ...
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