EXTRACTING BIOLOGICAL INSIGHTS FROM SINGLE MOLECULE MEASUREMENTS OF PROTEIN CONFORMATIONAL DYNAMICS USING K-SVD ALGORITHM
The conformational changes that biological macro-molecules undergo play a crucial role in functionality. These changes are measurable at the single molecular level using a technique known as single molecule Förster resonance energy transfer (smFRET). By measuring conformational changes at the single molecule (SM) level, distributions of physical properties, such as dwell times of the stepping motion observed in molecular motors, can be statistically modelled and monitored over time. However, there are several sources of error that are introduced when recording smFRET data. The recorded data ...
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