Multi-scale modeling and analysis via surrogate modeling techniques for in vivo knee loading predictions
Total knee replacement is a viable treatment for end-stage knee arthritis. With a greater number of younger patients opting for total knee replacement surgery, their increasingly active lifestyles will result in higher wear rates while decreasing the life expectancy of the tibial insert component of the knee replacement implant. In response to the eventuality of patients with more active lifestyles requiring knee replacement surgery, this research proposed to accurately estimate in vivo knee loading over a gait cycle through a multi-scale modeling approach. Estimates for knee loading were compared ...
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