Elucidating the function of the antisense RNA asdps in Escherichia coli
RNAs have emerged as major regulators of gene expression in both bacteria and eukaryotes. High-throughput sequencing techniques have uncovered a new type of RNA termed pervasive transcripts. Pervasive transcripts occur genome-wide and do not adhere to canonical gene boundaries. Despite the wide-spread occurrence of pervasive transcript, little is known about their function and initially they were considered to be noise. Bacterial genomes are compact, composed of 90% protein coding DNA. Therefore, most pervasive transcripts are antisense (as) to protein coding genes. Lybecker et. al identified ...
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