Validating the Reliable Change Index with Tensor-Based Morphometry
The Reliable Change Index (RCI) is a commonly used method for interpreting change in neuropsychological test scores over time. However, the RCI is a psychometric phenomenon that, to date, has not been validated by neuroanatomical evidence. Longitudinal neuroimaging and neuropsychological data from baseline and one-year follow-up visits were retrieved from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The RCI was used to identify participants showing reliable decline on the Auditory Verbal Learning Test (AVLT) delayed recall, the Trail Making Test part B (TMT-B), the ADNI-MEM ...
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