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dc.contributor.advisorPearson, James
dc.contributor.authorPizzey, Faith Katherine
dc.contributor.committeememberSubudhi, Andrew W.
dc.contributor.committeememberJacobs, Robert A.
dc.date.accessioned2019-05-07T21:45:38Z
dc.date.available2019-05-07T21:45:38Z
dc.date.submitted2019-05
dc.descriptionIncludes bibliographical references.
dc.description.abstractIntroduction: Caffeine is consumed daily by 90% of the United States population. In caffeine-naïve individuals, drinking caffeine increases dynamic cerebral autoregulation, but its influence in habitual users is unclear. We aimed to investigate the influence of caffeine upon dynamic cerebral autoregulation in habituated consumers. Methods: Twelve healthy subjects (age: 26 ± 6 yrs, Ht: 174 ± 12 cm, Wt: 75.4 ± 14.0 kg) completed three fluid ingestion trials in a double-blind, volume-controlled design. At baseline (PRE Drink), middle (MCAv; cm/s) and posterior (PCAv; cm/s) cerebral artery blood velocities were measured at baseline and during two thigh occlusion/release protocols to examine cerebral rate of regulation (ROR; 1/s). Subjects then drank (6.25ml/kg body mass) either caffeinated coffee (CAF; 4mg caffeine/kg body mass), decaffeinated coffee (DECAF) or water (WATER). Thirty minutes later baseline measurements and the assessment of ROR were repeated (POST Drink). Results: MAP decreased -13 ± 3 mmHg PRE Drink and -13 ± 2 mmHg POST Drink across all drinks following thigh cuff deflation. At PRE Drink, MCA ROR (p = 0.310) and PCA ROR (p = 0.585) were not different between trials. At POST Drink MCA ROR increased in the CAF trial relative to PRE Drink (0.37 ± 0.09, 1/s; p = 0.003) but was unchanged in DECAF (0.22 ± 0.09, 1/s; p = 0.105) and WATER trials (0.26 ± 0.11, 1/s; p = 0.052). At POST Drink MCA ROR was greater in the CAF relative to both DECAF (p = 0.001) and WATER trials (p = 0.007). At POST Drink, PCA ROR was greater in the CAF trial (0.36  0.10 1/s) relative to DECAF and WATER trials (0.23  0.08 and 0.25  0.08 1/s respectively, both p < 0.05). Relative to Pre Drink, PCA ROR was not different at POST Drink in any trial. (all p > 0.05). Conclusion: Dynamic cerebral autoregulation in middle and posterior cerebral arteries was greater with caffeine consumption in habituated consumers.
dc.identifierPizzey_uccs_0892N_10449.pdf
dc.identifier.urihttps://hdl.handle.net/10976/167087
dc.languageEnglish
dc.publisherUniversity of Colorado Colorado Springs. Kraemer Family Library
dc.relation.ispartofTheses
dc.rightsCopyright of the original work is retained by the author.
dc.titleImpact of Caffeine on Dynamic Cerebral Autoregulation in Habitual Consumers, The
dc.typeThesis
dcterms.cdm.subcollectionBiology
thesis.degree.disciplineCollege of Letters, Arts, and Sciences-Biology
thesis.degree.grantorUniversity of Colorado Colorado Springs
thesis.degree.levelMasters


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