Now showing items 1-10 of 15
Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
Author(s):Ganapathi Sankaran, Divya
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate ...
Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are ...
Single cell RNA sequencing unravels unique molecular determinants of ER+ breast cancer organ-specific metastasis
Author(s):Padilla Just, Nuria
Over half of all deaths from breast cancer are due to metastatic estrogen receptor positive (ER+) disease. Patients with ER+ breast cancer are at chronic and prolonged risk of relapse; overall survival upon detection of ...
Eya3 threonine phosphatase promotes triple negative breast cancer growth through PD-L1 regulation of the tumor adaptive immune response, The
The Eya family of proteins are critical developmental transcription factors that are highly expressed in early embryogenesis where they promote cell survival, proliferation, migration and invasion. Most Eya proteins are ...
Tryptophan catabolizing enzyme TDO2 as an immunotherapeutic target in breast cancer, The
Tryptophan catabolism is an attractive target for reducing tumor progression and improving antitumor immunity in multiple cancers. In triple-negative breast cancer (TNBC), tumor infiltration by CD8 T cells correlates with ...
Tryptophan catabolism promotes triple-negative breast cancer metastasis
The studies in this dissertation were designed to explore potential therapeutic targets in triple-negative breast cancer (TNBC) based on genes expressed under anchorage independent conditions since TNBC has the worse ...
Immune regulation of mammary gland involution reveals targets for postpartum breast cancer treatment
Author(s):Martinson, Holly Anna
Women within 5 years postpartum have increased incidence of breast cancer as well as a poorer prognosis compared to women who have never been pregnant. Our lab has proposed that the poor prognosis and increased incidence ...
Mechanistic and a prognostic role for the ETS transcription factor ESE-1 in HER2+ breast cancer, A
The ETS transcription factor ESE-1/Elf3 controls transformation in human mammary epithelial cells although precise mechanisms by which this occurs and the breast cancer subtype(s) in which ESE-1 is most functionally relevant ...
Evaluation of internet-based videoconference intervention of cognitive behavioral therapy for insomnia in breast cancer survivors in medically underserved areas of Colorado
Author(s):McCarthy, Michaela S.
Approximately 30-50% of breast cancer survivors experience insomnia versus 10-20% of the general population. This insomnia often originates with cancer treatment, but can become chronic and persist over the lifetime of ...
Adherence to adjuvant hormonal therapy in breast cancer survivors
Author(s):Grossman, Vicki Lynn
The purpose of this study was to examine the relationship between adherence and traumatic stress, depression, and symptom distress. The study also sought to determine whether or not non adherence was intentional or ...