Now showing items 1-10 of 14
Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
Contributor:Ganapathi Sankaran, Divya
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate ...
Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are ...
Evaluation of internet-based videoconference intervention of cognitive behavioral therapy for insomnia in breast cancer survivors in medically underserved areas of Colorado
Contributor:McCarthy, Michaela S.
Approximately 30-50% of breast cancer survivors experience insomnia versus 10-20% of the general population. This insomnia often originates with cancer treatment, but can become chronic and persist over the lifetime of ...
Regulation of MMP2/9 transport to the invadopodia during breast cancer cell invasion
Invadopodia-dependent degradation of the basement membrane plays a major role during metastasis of breast cancer cells. Basement membrane degradation is mediated by targeted secretion of various matrix metalloproteinases ...
Statistical methods for cancer screening
Contributor:Brinton, John Ty
Current methods for cancer screening trials are limited. We develop methods for power and sample size in cancer screening trials, and decision models for evaluating cancer screening strategies. The work is presented in ...
Context dependent roles of microRNA-150-5p in normal mammary gland development and breast cancer
Contributor:Heinz, Richard Edward
Profiling of RNA in mouse mammary epithelial cells (MECs) isolated during pregnancy and lactation revealed that most differentially expressed microRNA (miRNA) precipitously declined at lactation. Since miR-150 exhibited ...
Immune regulation of mammary gland involution reveals targets for postpartum breast cancer treatment
Contributor:Martinson, Holly Anna
Women within 5 years postpartum have increased incidence of breast cancer as well as a poorer prognosis compared to women who have never been pregnant. Our lab has proposed that the poor prognosis and increased incidence ...
Adherence to adjuvant hormonal therapy in breast cancer survivors
Contributor:Grossman, Vicki Lynn
The purpose of this study was to examine the relationship between adherence and traumatic stress, depression, and symptom distress. The study also sought to determine whether or not non adherence was intentional or ...
Role of the miR-106b-25 miRNAs in Six1-mediated breast cancer progression and metastasis, The
Contributor:Smith, Anna Lea
Nearly all deaths from breast cancer are a result of metastasis, highlighting the need for improved therapies to combat distant-stage disease. Our lab has previously demonstrated that Six1 mediates breast cancer metastasis. ...
Eya3 threonine phosphatase promotes triple negative breast cancer growth through PD-L1 regulation of the tumor adaptive immune response, The
The Eya family of proteins are critical developmental transcription factors that are highly expressed in early embryogenesis where they promote cell survival, proliferation, migration and invasion. Most Eya proteins are ...