Browsing University of Colorado Anschutz Medical Campus by Author "Agarwal, Rajesh"
Inhibition of lipid oxidation increases glucose metabolism and enhances 2-deoxy-2-[¹⁸F]fluoro-D-glucose uptake in prostate cancer mouse xenografts Author(s):Schlaepfer, Isabel R.; Glodé, L. Michael; Hitz, Carolyn A.; Pac, Colton T.; Boyle, Kristen E.; Maroni, Paul; Deep, Gagan; Agarwal, Rajesh; Lucia, Scott M.; Cramer, Scott D.; Serkova, Natalie J.; Eckel, Robert H.
Pancreatic cancer chemoprevention and intervention strategies employing a natural agent- bitter melon juice Author(s):Dhar, Deepanshi
Date Submitted:2018With each passing decade, pancreatic cancer (PanC) is consistently emerging as an imminent threat to human population. Conventional therapies are proving to be of marginal relevance given that PanC associated fatalities ...
Author(s):Alsaleh, Nasser Bader
Date Submitted:2018Engineered nanomaterials (ENMs) are being utilized in a wide range of consumer and medical products. This leads to increased human exposure with potential adverse effects. Silver nanoparticles (AgNPs) are one of the most ...
Design, synthesis and evaluation of anti-tumor agents, targeting T-cell factor driven colorectal cancer, The Author(s):Abraham, Adedoyin David
Date Submitted:2018Colorectal cancer (CRC) is one of the most prevalent cancer types in the world. Recent statistics show that CRC is the third most common cancer among men and women in the United States, accounting for up to 50, 000 deaths, ...
Adverse effects of low molecular weight polycyclic aromatic hydrocarbons on alveolar type II pneumocytes Author(s):Osgood, Ross
Date Submitted:2017Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs) are ubiquitous, prevalent, and understudied environmental pollutants that present a worldwide human health concern. The purpose of this dissertation project ...
Date Submitted:2016This thesis investigates the mechanism of anti-tumor action of 19-substituted benzoquinone ansamycins (19BQAs). Benzoquinone ansamycins (BQAs) are heat shock protein-90 (Hsp90) inhibitors, but the clinical use of BQAs has ...
Date Submitted:2013Sulfur mustard (2,2-dichlorodiethyl sulfide; SM), a bifunctional alkylating chemical warfare agent, forms adducts and crosslinks with DNA, RNA and proteins. 2-Chloroethyl ethyl sulfide (CEES), a monofunctional alkylating ...
Date Submitted:2016Non-melanoma skin cancers (NMSCs) are a growing problem given that solar UVB radiation exposure is increasing due to depletion of the atmospheric ozone layer. Better preventive methods are urgently required to reduce ...
Silibinin exerts cancer chemopreventive efficacy via targeting prostate cancer cell and cancer-associated fibroblast interaction Author(s):Ting, Harold J.
Date Submitted:2015Prostate cancer (PCA) kills thousands in the US each year despite massive investment and success in improving early detection and treatment. Importantly, even successful treatment is still associated with persistent and ...
Investigating the multi-targeted anti-cancer and chemopreventive potential of GSE in pre-clinical models of colorectal cancer Author(s):Derry, Molly Marie
Date Submitted:2013Colorectal cancer (CRC) is the third leading cause of cancer-associated deaths in the world; in this regard, there is an interest in cancer prevention and treatment strategies. Colon carcinogenesis involves a number of ...
Anti-cancer and chemopreventive efficacy of grape seed extract against head and neck squamous cell carcinoma through cellular metabolism Author(s):Shrotriya, Sangeeta
Date Submitted:2013Grape seed extract (GSE), rich in proanthocyandins, has been proven to possess anti-cancer and chemopreventive efficacy in various organs associated malignancies. However, the detailed mechanistic insight for its efficacy ...