HIV TAT mediation of redox sensitive transcription factors in pulmonary vascular cells
Chronic HIV infection in the era of anti-retroviral therapy is associated with dramatically increased risk of developing severe cardio-pulmonary disease. Common to these diseases are increased oxidative burden and chronic inflammation despite low viremia and restoration of CD4+ T-cell levels. Soluble viral factors are heavily implicated in these disease processes, including the HIV Transactivator of Transcription (Tat). Tat is produced in high levels during infection and secreted from infected cells into circulation where it is internalized by bystander cells and is known to regulate inflammatory ...
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