Chronic interleukin-1 exposure triggers selective expansion of CEBPA-deficient multipotent hematopoietic progenitors
The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic genetic changes that occur in these disorders and how they impact cell fate decisions. The Adaptive Oncogenesis Model proposes that a context that perturbs homeostasis (e.g. chronic inflammation) can select for phenotypes that are adaptive in that perturbed context. Chronic exposure to the pro-inflammatory cytokine interleukin-1 beta (IL-1β) impairs normal hematopoiesis by ...
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