Mechanistic studies of GCN5 acetylation during craniofacial development and chondrocyte maturation
Formation of the craniofacial skeleton involves the invasion of the migratory cranial neural crest (cNCC) into the pharyngeal arches, where they will terminally differentiate and contribute to the bone and cartilage that makes up the facial skeleton. The regulation of the terminal differentiation programs of cNCC has not been well explored, including how epigenetic enzymes participate in these pathways. The lysine acetyltransferase GCN5 is required for murine development and participates in numerous regulatory pathways throughout development. The catalytic activity of GCN5 is also required for ...
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