Tuba1a microtubules establish the foundations for neuronal function
Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of alpha/beta-tubulin dimers, drives neurite outgrowth, promotes neuronal growth cone responses, and facilitates intracellular transport of critical cargoes during neurodevelopment and in adulthood. The mechanisms by which neurons regulate microtubule network assembly and organization to respond appropriately to external cues are largely unknown. Cells express different alpha and beta tubulin genes, or isotypes, providing one potential ...
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