Evaluating potential mechanisms of cardiovascular damage in women across the lifecourse
The risk of cardiovascular disease (CVD) is low in premenopausal women, but after menopause it increases to match that in men. Most of this increased risk has been attributed to loss of the favorable effects of endogenous estrogen on CVD risk factors; however, the loss of estrogen is unable to explain all of the risk. Furthermore, in type 1 diabetes, CVD risk in premenopausal women already matches that in men, suggesting that premenopausal women with type 1 diabetes do not benefit from endogenous estrogen as premenopausal women without diabetes do. Traditional CVD risk factors and the higher ...
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