Transcriptional regulation of the developing retina
The retina is a complex stratified neural tissue required for all mammalian vision. During development, tightly controlled transcriptional regulation drives diversification from a homogenous population of retinal progenitor cells into seven major types and dozens of subtypes of cells. Here, we explored the role of the transcription factors Otx2, Prdm1, Prdm13, and Vsx2 in driving the formation of specific neurons from retinal progenitors. We first showed that PRDM13 is expressed in a subset of developing amacrine interneurons. Loss of Prdm13 leads to a 25% reduction in amacrine cells and disruption ...
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Goodson, Noah Branch
Brzezinski, Joseph A.