Early determinants of CD8 T cell fate in the response to subunit immunization
While vaccination represents one of the most impactful developments in the history of medicine, successful vaccines still overwhelmingly rely on empirically-derived formulations targeting humoral responses. With the explosion of cancer-focused immunotherapies and the substantial need for the treatment of humoral-resistant diseases such as HIV and TB, the field of vaccinology is undergoing a transition toward therapeutic intervention and cell-mediated immunity focus, and thus our current approach to vaccine design is in need of a substantial update. Some current vaccine strategies are able to ...
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