Extreme physiology and short on time: quantitative and qualitative changes in the heart proteome and brown adipose transcriptome underlie the dynamic phenotype of hibernation
Mammalian hibernation is characterized by a deep reduction in basal metabolic rate and body temperature in order to maximize energy savings during times of low food availability and harsh environmental conditions. These physiological extremes are lethal to non-hibernators, yet because hibernators are broadly distributed among mammalian lineages, the genes that underlie the phenotype are hypothesized to be common to all mammals, although differentially expressed. Because of their natural phenotypic plasticity, hibernators are excellent models for identifying natural solutions to improve the human ...
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Grabek, Katharine Rosalie
Martin, Sandra L.
Access restricted until November 30, 2014.