Role of Pard3 in Schwann cell development, The
Schwann cells are the myelin forming glial of the peripheral nervous system and are required for the rapid transmission of sensory and motor information between the central nervous system and the peripheral tissues. During development, the cells fated to become myelinating Schwann cells undergo a stepwise sequence of events including delamination from the neuroepithelium, directed migration into peripheral tissue, axon ensheathment and synthesis of myelin membrane. How Schwann cells regulate the transitions between these distinct behaviors is unclear. These dynamic developmental steps require ...
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