Immune regulation of mammary gland involution reveals targets for postpartum breast cancer treatment
Women within 5 years postpartum have increased incidence of breast cancer as well as a poorer prognosis compared to women who have never been pregnant. Our lab has proposed that the poor prognosis and increased incidence of postpartum breast cancers are possibly due to mammary gland remodeling following pregnancy, an event known as postpartum involution. Using rodent models and human breast tissue, characterization of postpartum involution has shown that the remodeling programs resemble activated wound healing programs known to be tumor promotional. We hypothesize that immune cells within the ...
(For more, see "View full record.")
Martinson, Holly Anna
Access restricted until May 31, 2016.