Epigenetic and Co-transcriptional regulation of B lymphocyte development and function
B lymphocyte development and function are tightly regulated processes that are dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Several factors contribute to the transcriptional regulation of B lymphocyte development including chromatin remodeling complexes and RNA splicing machinery. These epigenetic and co-transcriptional regulatory mechanisms influence the accessibility of genes, their transcription and their translational efficiency. Mis-regulation of these pathways contributes to profound cellular and molecular deficiencies including ...
(For more, see "View full record.")