Proteomic insights into acylation events in alcoholic liver disease and heart failure
Protein post translational modifications (PTMs) and their regulatory enzymes play a significant role in health and disease. The research undertaken in this dissertation involves the application of a novel mass spectrometry assay used to investigate sirtuin biology, metabolism, and PTMs in a translational model of alcoholic liver disease (ALD) and human ischemic failing cardiac myofibrils. Chronic alcohol consumption is a causal factor in a variety of diseases, including ALD. While ALD develops through several mechanisms, one major mechanism contributing to the pathology of ALD is mitochondrial ...
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