Regulation of myeloid cell IFNGR1 by types I and II interferon, The
Types I and type II interferon (IFNα/β and IFNγ) are cytokines that are critical mediators of myeloid cell activity during immune responses. The type II IFN (IFNγ) binds IFNGR to regulate myeloid cell gene expression and drive pro-inflammatory M1-type macrophage activation that enhances antitumor and antibacterial immune responses. Type I IFNs bind their receptor (IFNAR) and induce interferon-stimulated genes required for antiviral immunity. Unlike IFNγ, type I IFNs are detrimental during intracellular bacterial infections like Listeria monocytogenes (Lm). Our lab has shown that type I IFNs ...
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