Role of JMJD5 and JMJD6 in transcriptional pause release, The
30-60% of genes in higher eukaryotes are regulated by promoter-proximal pausing of Pol II, thus representing a major transcription regulatory mechanism. Previously, we reported that two orphan Jumonji C domain (JmjC)-containing proteins, JMJD5 and JMJD7, have divalent cation-dependent protease activities that preferentially cleave histone tails containing methylated arginines. After the initial specific cleavage, JMJD5 and JMJD7, acting as aminopeptidases, progressively digest the C-terminal products to generate “tailless nucleosomes”, which could release the promoter-proximally paused RNA ...
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