Risk of ventricular arrhythmias/cardiac arrest associated with selective serotonin reuptake inhibitor (SSRI) use among pediatric and young adult population
Selective serotonin reuptake inhibitors (SSRIs) have been associated with increased risk of QT prolongation and life-threatening arrhythmia. Despite being the most commonly prescribed antidepressant, the risk of this adverse event in the pediatric population is unknown. Using data from a quaternary care pediatric center linked to administrative data, an algorithm with a 95% positive predictive value (PPV) for identifying out-of-hospital ventricular arrhythmia and cardiac arrest from cardiac cause was selected, improving upon the adult algorithm PPV of 41%. Using the IQVIATM Health Plan Claims ...
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