Pharmacokinetics and renal safety of tenofovir with ledipasvir/sofosbuvir
Individuals may be infected with Hepatitis C Virus (HCV) and the Human Immunodeficiency Virus (HIV) due to shared routes of transmission. HCV is curable with 8-12 weeks of direct-acting antiviral (DAA) therapy. However, those with HIV infection must take antiretroviral medications (ARV) chronically to suppress viral replication. ARVs and DAAs have overlapping clinical pharmacology and are therefore subject to drug-drug interactions. The consequences of an unexpected drug interaction with antiviral therapy can be significant and include toxicities, therapeutic failure, and/or the development of ...
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