High altitude pregnancy as a model for uteroplacental hypoxia : identifying therapeutic targets for preventing fetal growth restriction
Arguably a population with the greatest unmet need for therapies is pregnant women. Despite the risk of maternal and offspring perinatal morbidity and “programming” of adult disease in the offspring, there is a lack of therapies for treating pregnancy disorders. As many pregnancy disorders involve uteroplacental hypoxia, high-altitude (HA, > 2500m) pregnancy is an effective model in which to isolate effects of hypoxia during pregnancy to address mechanisms by which uteroplacental hypoxia might be therapeutically treated. HA pregnancy is associated with reduced uterine artery blood flow and fetal ...
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