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dc.contributor.advisorFrank, Guido
dc.contributor.advisorFelsen, Gidon
dc.contributor.authorDeguzman, Marisa
dc.contributor.committeememberTregellas, Jason
dc.contributor.committeememberThompson, John
dc.contributor.committeememberSakai, Joseph
dc.date.accessioned2019-05-17T20:03:31Z
dc.date.available2020-05-16T19:43:49Z
dc.date.submitted2019
dc.descriptionIncludes bibliographical references.
dc.descriptionSpring
dc.description.abstractAnorexia nervosa (AN) is a severe eating disorder that predominantly affects young females and typically begins in adolescence. These studies aimed to understand the underlying neurobiology of adolescent AN by assessing brain response to primary and secondary rewards. The first study used a longitudinal design to understand not only the effect of weight restoration on brain function, but to try to establish heightened reward system responsiveness at a low weight as a predictive biomarker of AN treatment outcomes. The second study replicated this association of reward sensitivity and treatment outcome and additionally revealed a top-down pattern of effective connectivity that may be related to the fear-driven cognitive control over homeostatic hunger signals. Both of these studies also linked elevated brain response to rewards with pertinent characteristics like sensitivity to punishment and harm avoidance through validated self-report measures. The final study expands upon previous evidence of reward sensitivity in healthy adolescents compared to adults and points to a relationship between neural taste discrimination ability and body weight that may be an important point to consider in isolating risk factors for eating disorder development. Together, these studies reveal altered reward system function in low weight AN and emphasize that adolescence is a critical period for brain development that should be a major focus in future investigations of AN onset, maintenance, and recovery.
dc.identifierDEGUZMAN_ucdenveramc_1639D_10638.pdf
dc.identifier.urihttps://hdl.handle.net/10968/3460
dc.languageEnglish
dc.publisherUniversity of Colorado at Denver, Anschutz Medical Campus. Health Sciences Library
dc.rightsCopyright of the original work is retained by the author.
dc.rights.accessEmbargo Expires: 05/16/2020
dc.subject.meshAnorexia Nervosa
dc.subject.meshFeeding and Eating Disorders
dc.titleReward processing in healthy adolescents and adolescents with Anorexia nervosa
dc.typeThesis
dcterms.embargo.expires2020-05-16
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Colorado at Denver, Anschutz Medical Campus
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)


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