High incidence of SMAD4 loss and associated susceptibility to combined PARP inhibition with radiation in head and neck squamous cell carcinomas
SMAD4 loss is associated with increased survival and genomic instability, and contributes to the initiation/progression of head and neck squamous cell carcinoma (HNSCCs). SMAD4 loss, while not directly targetable, is associated with multiple targetable pathways that require further studies. Reports vary regarding the frequency of SMAD4 loss in HNSCCs, and accurate detection of genetic SMAD4 loss is critical to determine prognosis and therapeutic interventions. We developed a SMAD4 fluorescence in situ hybridization (FISH) assay to identify chromosomal SMAD4 loss at the single cell level. SMAD4 ...
(For more, see "View full record.")