Investigating intrinsic mechanisms of microtubule dynamic instability and its contribution to chromosome segregation
The dynamic microtubule network is an essential cytoskeleton component that facilitates the organization of almost all eukaryotic cells, and is most notable for its role in chromosome segregation. Despite the conversed role of microtubules in cell division, there is limited understanding of how intrinsic molecular properties of the tubulin heterodimers contribute to the activity of the network. What modules of the tubulin heterodimer might cells target to change the dynamic behavior of their microtubule networks? And how might these modules contribute to the functional diversity of the microtubule ...
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