Targeting the complement pathway in lung cancer progression
The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also paradoxically associated with tumor progression. In this thesis we report mechanistic insights into the role of complement activation in the progression of multiple murine lung adenocarcinomas using an immunocompetent orthotopic models of lung cancer. After tumor engraftment, we observed systemic and local activation of the complement cascade as reflected by elevated levels of the key regulator C3a in plasma samples and deposition of C3b ...
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