Dysregulation of the host immune response by the human papillomavirus oncoprotein E7
High-risk human papillomaviruses (HPVs) are causally associated with multiple cancers. HPV persistence is necessary for cancer progression, but factors that drive cancer progression and how HPV evades the host immune response during persistence remain under defined. The HPV oncoprotein E7 enacts numerous functions within the infected cell, including disrupting immune mechanisms. I have identified two novel mechanisms by which the HPV oncoprotein E7 promotes immune evasion and cancer progression. APOBEC3 (A3) proteins are cytidine deaminases that play a role in immunity and possibly cancer ...
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