B cell subset contributions to the primary HIV antibody response
Despite global efforts, a preventative HIV vaccine remains elusive. The correlates of protection against HIV infection are as yet undefined, but clues can be drawn from potent antibodies able to neutralize diverse HIV strains. A series of potent broadly-neutralizing HIV antibodies have recently been isolated from B cells of HIV-infected individuals. VRC01 represents a subset of these antibodies that mediate neutralization with a restricted set of IGHV genes. The memory B cells that expressed these antibodies were isolated years after infection. Therefore, the B cell subpopulation from which they ...
(For more, see "View full record.")