Tryptophan catabolizing enzyme TDO2 as an immunotherapeutic target in breast cancer, The
Tryptophan catabolism is an attractive target for reducing tumor progression and improving antitumor immunity in multiple cancers. In triple-negative breast cancer (TNBC), tumor infiltration by CD8 T cells correlates with improved prognosis, and a significant effort is underway to improve CD8 T cell antitumor activity. In this study, primary human immune cells were used to demonstrate that the tryptophan catabolite kynurenine induces CD8 T cell death and an expansion of regulatory T cells, and that anchorage-independent TNBC utilizes the tryptophan catabolizing enzyme tryptophan 2,3-dioxygenase ...
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