Liver fatty acid-binding protein: analyses of 4-HNE adduction, lipid regulation, and the oxidative stress response in a model of early-stage alcoholic liver disease
Oxidative stress and lipid peroxidation are proposed to be heavily involved in the progression of alcoholic liver disease (ALD). The work presented in this dissertation evaluates the oxidative modification of the liver fatty acid-binding protein (L-FABP) by the reactive aldehyde 4-hydroxynonenal (4-HNE). Utilizing proteomics based approaches, L-FABP was found to be modified with 4-HNE in both rats and mice chronically treated with alcohol. Additional studies revealed that the levels of this protein were significantly decreased due to chronic ethanol ingestion. Further analysis with recombinant ...
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