Fibrinolysis shutdown following injury : pathologic hypercoagulability driving delayed morbidity and mortality
Trauma patients appear to manifest unique coagulation phenotypes post-injury, and >50% of all severely injury trauma patients present with impairment of their fibrinolytic system. Fibrinolysis shutdown, defined by thrombelastography (TEG) LY30 (percent of clot degraded 30-minutes after achieving maximum clot strength) <0.9%, has been associated with increased mortality compared to trauma patients with moderate level fibrinolysis (LY30 0.9-2.9%). To date, there is a poor understanding of the incidence and mechanisms that drive fibrinolysis resistance. We hypothesized that tissue injury drives ...
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