2017 to Current
Recent Submissions
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Internal compass and a sacred burden: a phenomenological inquiry of a nurse’s experience of sacred moments during patient care, An
Purpose: The purpose of this qualitative descriptive study was to describe the essence of a sacred moment for a nurse during patient care, and to explore the impact of the phenomena on nursing practice and commitment to ... -
Utilization of complementary and integrative healthcare by people with spinal cord injury
Complementary and integrative healthcare (CIH) describes approaches outside of conventional medical practices. There is an increasing trend of CIH use in the US, but little evidence for efficacy and safety. People with ... -
Regulation of cancer cell migration and invasion by RAB40B
Cell migration is a complex and highly regulated process that involves coordinated changes in signaling, membrane trafficking and cytoskeleton dynamics, and it is well-established that extracellular matrix (ECM) degradation ... -
Basal cytokeratins regulate tumorigenic and aggressive properties in breast cancer cells
Cytokeratins (CKs) are intermediate filaments (IF) that provide essential structural support for epithelial cells. Humans express 54 unique CKs in a cell- and tissue-type dependent manner. Some functional roles of these ... -
Chronic pain and the family: a mixed-methods research synthesis
Chronic pain is recognized as a public health and family crisis for many Americans and causes profound changes that dramatically alter family patterns of interaction and involvement. Despite decades of research, little is ... -
Antimicrobial drug use and antimicrobial resistance in companion animal medicine
Antimicrobial resistance (AMR) is a persistent global public health threat. Antimicrobial drug (AMD) use is a major driver of the development of AMR. AMD use in companion animal medicine in the United States is a relatively ... -
Beyond killing: precursor ribosomal RNA as a biomarker for effective mycobacterial treatment
Mycobacteria range from environmental bacteria to opportunistic and obligate pathogens. Mycobacterium tuberculosis kills ~1.5 million people each year and incidence of drug-resistant tuberculosis increases yearly. Similarly, ... -
Structure-activity study into the development of small molecule RSK2 kinase inhibitors, A
The RSKs are a family of kinases that are the downstream effectors of the Ras/Raf/MEK/ERK pathway that is often activated in many cancers including leukemias (1). Several small-molecule RSK inhibitors have been developed ... -
Lived experience of nurse leaders practicing within Watson Caring Science framework creating a caring, healing environment for staff, The
Creating a caring, healing environment is an integral aspect of the nursing profession; however, there is no formal consensus on what constitutes a caring, healing environment. This descriptive, qualitative study was ... -
Pharmacologic PTEN upregulation: a novel approach to maintain smooth muscle cell homeostasis following vascular injury
The primary aim of this thesis work was to identify compounds that upregulate phosphatase and tensin homolog (PTEN) expression in smooth muscle cells (SMCs), with the expectation that PTEN upregulation would inhibit ... -
Impact of iron and copper homeostasis on clofazimine activity and consequences for killing of mycobacteria, The
The anti-leprosy drug clofazimine (CFZ) was recently shown to improve outcomes in treatment of multidrug-resistant tuberculosis (TB); however, the mechanism of action of CFZ and resistance mechanisms remain unclear. We ... -
Role of Snx3 in mammalian neural tube closure, The
The earliest step in the development of the mammalian brain and spinal cord requires complex and coordinated morphogenetic movements, dynamic tissue remodeling, interactions between cells and tissues, cellular signaling, ... -
Assessment and evaluation of a crosswalk between the functional independence measure and the continuity assessment record and evaluation
Background: Assessment of functional outcome is a major initiative for facilities engaging in post-acute care. Unfortunately across time, the various types of post-acute care facilities had developed measures to assess ... -
Role of NLRP inflammasomes in melanoma, The
Melanoma remains the deadliest form of skin cancer despite advances in intervention strategy and the development of targeted and immunomodulatory therapies. Therapeutic responses are short-lived as patients continue to ... -
Exploring the structure-function relationships of pathogenically relavent flaviviral RNAs
Flaviviruses such as Yellow Fever, Dengue, West Nile, and Zika are arthropod borne, enveloped, positive-sense single-stranded RNA viruses that infect millions of people around the world. In particular, Dengue is estimated ... -
Identification and evaluation of population-level interventions for the prevention of postpartum depression, The
Postpartum depression affects an estimated 800,000 American women annually and can have long-term adverse consequences. Socioeconomic factors (e.g., poverty and material hardship) increase the risk of postpartum depression. ... -
Shaping the postsynaptic landscape: understanding the role of neuronal activity in local secretory and endocytic protein trafficking dynamics
Neuronal development, morphology, excitability and synapse function rely on the ability to maintain and dynamically regulate the repertoire of channel, receptor and adhesion integral membrane proteins presented on the cell ... -
Neuronal and microglial interactions with oligodendrocytes regulate myelin sheath formation and elimination
During development, oligodendrocytes contact and ensheathe numerous axons with myelin, a proteolipid-rich membrane that increases conduction velocity and provides trophic support. After myelin sheath formation, some wraps ... -
Molecular mechanisms underlying mRNA localization to myelin sheaths
Myelin is a specialized membrane produced by oligodendrocytes that insulates and supports axons. Oligodendrocytes extend numerous cellular processes, as projections of the plasma membrane, and simultaneously wrap multiple ... -
Determinants of Plasmodium falciparum liver stage infection: receptors, innate immunity and host genetics
Malaria is a major global health burden, with roughly half the world’s population at risk of contracting the disease. Malaria is caused by the intracellular protozoan parasite of the genus Plasmodium; it has two stages of ...
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