2017 to current - CU Anschutz Theses and Dissertations
Recent Submissions
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Comparison of one year post-injury outcomes between intensive locomotor training and conventional therapy after motor incomplete spinal cord injury
Background: Spinal cord injury (SCI) is often a devastating condition that negatively affects an individual’s physical, psychological, and social well-being requiring extensive rehabilitation. The majority of all SCIs are ... -
Investigation of traditional and deep neural sequence models for biomedical concept recognition
The goal of this dissertation is to improve state-of-the-art biomedical concept recognition. The task has a long history, but performance improvement is still an open research question. The dissertation has three main ... -
Lysophosphatidic acid suppression of CD8 T cell signaling and function
Immunotherapies have demonstrated the utility of targeting the immune system for eradication of tumors, yet a majority of patients remain refractory to such treatments. Therefore, further advances in our understanding of ... -
Human maternal obesity in the development of nonalcoholic fatty liver disease in a germ-free mouse model : identifying the role of the infant gut microbiome
Maternal metabolism and obesity contribute significantly to the risk of obesity and non-alcoholic fatty liver disease (NAFLD) in the next generation, however the causal drivers of this relationship are currently unclear. ... -
Pharmacokinetics and renal safety of tenofovir with ledipasvir/sofosbuvir
Individuals may be infected with Hepatitis C Virus (HCV) and the Human Immunodeficiency Virus (HIV) due to shared routes of transmission. HCV is curable with 8-12 weeks of direct-acting antiviral (DAA) therapy. However, ... -
Explicating nurse care coordination processes in the context of rural delivery systems
Care coordination is one of six National Quality Strategy priorities for transforming health care quality to improve population health and value in health care (AHRQ, 2017). While the participation in care coordination ... -
Comparison of two-stage FPCA and bayesian mixture models applied to physical activity accelerometer data : pattern identification and group classification, A
Collectively, society has begun to borderline obsess with ability to monitor our physical activity. A plethora of devices now exist to monitor steps, heart rate, sleep pattern, and many other metrics, giving individuals ... -
High altitude pregnancy as a model for uteroplacental hypoxia : identifying therapeutic targets for preventing fetal growth restriction
Arguably a population with the greatest unmet need for therapies is pregnant women. Despite the risk of maternal and offspring perinatal morbidity and “programming” of adult disease in the offspring, there is a lack of ... -
Exploring the foundation of clinician's judgment when assigning the Apgar score
Background: The Apgar score (AS) is the only tool to quantify neonatal status immediately after birth. Prior research indicates that the AS has multiple weaknesses in regards to validity and reliability including poor ... -
Reward processing in healthy adolescents and adolescents with Anorexia nervosa
Anorexia nervosa (AN) is a severe eating disorder that predominantly affects young females and typically begins in adolescence. These studies aimed to understand the underlying neurobiology of adolescent AN by assessing ... -
Building a brain : interrogating how the α-tubulin gene TUBA1A contributes to neurodevelopment
The importance of microtubules during the development and appropriate function of the nervous system has long been acknowledged. The highly complex coordination of cell proliferation, differentiation, migration, neuronal ... -
Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are ... -
Relationship between nurse manager practice environments and nurse manager outcomes, The
This research study is a secondary data analysis that examines the relationship between personal/positional demographics and the Nurse Manager Practice Environment (NMPE) and the relationship between NMPE and nurse manager ... -
Developmental origins and heterogeneity of the neocortical oligodendrocyte lineage
The formation of neocortical circuits during development requires coordinated production of excitatory projection neurons, astrocytes, and oligodendrocytes from a shared pool of neural progenitor cells. While we are beginning ... -
Characterizing MIR137HG variation and contribution to risk for schizophrenia
The MIR137HG gene encoding microRNA-137 (miR-137) is associated with risk for schizophrenia (SZ) through genetic and functional studies, however, the molecular mechanisms underlying risk remain unknown. Through this work ... -
Mechanisms of immunoglobulin somatic hypermutation during retroviral infection
A potential HIV-1 vaccine should stimulate a broadly neutralizing antibody (bNAb) response, which overcomes HIV-1 mutational escape to typical NAb responses that develop by covering a wide variety of HIV-1 strains. bNAbs ... -
Applications of policy analysis on health outcomes
Policy analysis as a tool for determining the effects of health outcomes is an increasingly common practice but has been limited in scope to considering largely federal or state law changes only. My dissertation demonstrates ... -
Supine sleep positioning among high-risk U.S.-born infants : the persistent preterm/term and non-Hispanic black/non-Hispanic white racial disparity
Objectives: 1) Assess the racial disparity in SSP between NHB and NHW early preterm (<34 weeks) and late preterm (34-36 weeks) infants, 2) Measure the impact of states’ prioritization of safe infant sleep in their 2010 ... -
High incidence of SMAD4 loss and associated susceptibility to combined PARP inhibition with radiation in head and neck squamous cell carcinomas
SMAD4 loss is associated with increased survival and genomic instability, and contributes to the initiation/progression of head and neck squamous cell carcinoma (HNSCCs). SMAD4 loss, while not directly targetable, is ... -
Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate ...
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