2017 to current - CU Anschutz Theses and Dissertations
Recent Submissions
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Investigating the role of TP63 in the squamous cell carcinoma of the skin, and head and neck cancer
Cutaneous, and Head and Neck Squamous cell carcinoma (cSCC and HNSCC), are two of the most common cancers worldwide, resulting in approximately 13,700 deaths (combined) every year in the United States. Despite their high ... -
Disrupted co-expression network method (DisCoNet) : a hybrid approach to assessing gene module construction in saline versus ethanol treated recombinant inbred mice
Continued research in genomics is confirming that gene products operate together to perform biological functions, and that very few phenotypes result from the differences in a single gene. The challenge is to determine ... -
Evaluation of intrinsic and extrinsic factors associated with injury rates and patterns among recreational skiers and snowboarders at a Colorado ski resort
Over 10 million people participate in skiing and snowboarding in the United States (U.S.), including 500,000 Colorado residents. Accordingly, an estimated 600,000 patients with skiing- or snowboarding-related injuries are ... -
Assessing the impact of two statewide family planning initiatives on birth rates : outcomes from the Colorado Family Planning Initiative and the Iowa initiative to reduce unintended pregnancies
The Title X family planning program has provided low-income women and teens access to family planning services for over 40 years through its network of about 4,000 clinics nationwide. Expanding access to long-acting ... -
Effect of prescription medication exposure on Stevens-Johnson syndrome (SJS), Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome (SJS-TEN), and toxic epidermal necrolysis (TEN) in a U.S. commercially insured population
Associations between prescription medication exposure and SJS, SJS-TEN, and TEN (SJS/TEN) have not been studied in the U.S. commercially insured population. It is unclear if medication exposures that occur prior to the one ... -
New insights into the mechanism of silver nanoparticle-mediated mast cell activation
Engineered nanomaterials (ENMs) are being utilized in a wide range of consumer and medical products. This leads to increased human exposure with potential adverse effects. Silver nanoparticles (AgNPs) are one of the most ... -
Investigating intrinsic mechanisms of microtubule dynamic instability and its contribution to chromosome segregation
The dynamic microtubule network is an essential cytoskeleton component that facilitates the organization of almost all eukaryotic cells, and is most notable for its role in chromosome segregation. Despite the conversed ... -
System-level factors associated with healthcare utilization among young adults with congenital heart disease transitioning to adult cardiac care settings using social network analysis
With medical and surgical advances over the past 60 years, more young adults with congenital heart disease are surviving into adulthood. Unfortunately, adolescence is a time when many fail to transition into adult care ... -
International prevalence and cross-national consistency of sociodemographic risk factors for corporal punishment and harsh verbal punishment of children
Corporal punishment has been an accepted and nearly ubiquitous parenting behavior across varied cultures and historical periods, but a growing body of research has raised questions about both the ethics of the practice and ... -
Perceptions of usability and workflow in an electronic medication history assessment tool (eMedHAT®)
Background/Rationale: Incomplete or inaccurate medication histories are common in primary care, and it is critical to improve the accuracy of patient-reported medication utilization for patient safety. Computer applications ... -
Regulating forces in cells : from dynein to microtubules to DNA
Mitotic spindle positioning is paramount to proper genome segregation and cell division. Where the spindle is placed in a dividing cell determines cell fates. How do cells control where the mitotic spindle is positioned? ... -
Hepatitis C prevalence, healthcare utilization and treatment outcomes in a large, integrated healthcare system
Hepatitis C (HCV) infects the liver, affecting its function, and may progress to liver cirrhosis and cancer. New direct-acting antiviral (DAA) treatments allow patients to achieve sustained virologic response (SVR) at ... -
Physical stability and aggregation of antibody based therapeutics
Worldwide, therapeutic proteins greatly benefit millions of patients by successfully treating a wide range of human diseases. Antibody drug conjugates (ADCs) are a new class of antibody based therapeutics that combine the ... -
Biomarkers of therapeutic response in bladder cancer
Treatment of muscle-invasive bladder cancer (MIBC) typically includes systemic cisplatin-based chemotherapy. Despite being a mainstay first-line treatment for 3 decades, the response rate to this chemotherapy is only 50%. ... -
Determining the mechanism of Aβ-induced NMDA receptor dysfunction
Beta amyloid (Aβ) triggers elimination of excitatory synaptic connections in the central nervous system, an early manifestation of Alzheimer’s disease. Oligomeric assemblies of Aβ peptide associate with excitatory synapses ... -
Re-linkage to HIV care among persons living with HIV (PLWH) with a gap in care of six months or more
Despite widespread attention to the HIV care continuum over the past several years, little attention has focused on the 45% of PLWH that are not retained in care who are responsible for more than 60% of new HIV infections. ... -
Targeting the complement pathway in lung cancer progression
The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also paradoxically associated with tumor progression. In this thesis ... -
Epstein-Barr virus gp350 role in T-cell tropism and protection against infection : implications for an EBV vaccine
Epstein-Barr virus (EBV) is a human specific gammaherpesvirus that infects greater than 95% of the world’s population. EBV does not typically cause severe disease, however in some cases it is associated with malignancies ... -
Physical function, rehabilitation, and hospitalizations within medically complex older adult populations
Impaired physical function among older adult populations has a high cost—both in terms of societal costs, quality of life, and monetary costs to the healthcare system. A major driver of healthcare costs related to impaired ... -
Single cell RNA sequencing unravels unique molecular determinants of ER+ breast cancer organ-specific metastasis
Over half of all deaths from breast cancer are due to metastatic estrogen receptor positive (ER+) disease. Patients with ER+ breast cancer are at chronic and prolonged risk of relapse; overall survival upon detection of ...
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