2017 to Current
Recent Submissions
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Discovery of small molecule inhibitors targeting oncogenic CHD1L with preclinical activity in colorectal cancer
The majority of colorectal cancers arise from dysregulation in the Wnt signaling pathway. Aberrant Wnt signaling is associated with tumor formation, metastasis, and drug resistance. Many current therapeutic strategies ... -
Variable IL-2Rβ expression and organization in signaling and disease
Delivery of recombinant IL-2 and IL-15 and the targeting of their receptors has emerged as a promising intervention strategy for treatment of autoimmunity, chronic infectious diseases and cancer. Therefore, a better ... -
Clinical utility of incorporating single-axis 3D tomography to the electron microscopic examination of ciliary biopsies, The
Primary ciliary dyskinesia (PCD) is a congenital disease of the respiratory airways characterized by abnormal cilia structure and function. Clinical symptoms of the disease may include situs inversus, bronchiectasis, and ... -
Tuba1a microtubules establish the foundations for neuronal function
Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of alpha/beta-tubulin dimers, drives neurite outgrowth, ... -
Novel requirements of the synaptic transmembrane protein Csmd2 in neuronal maturation and structural plasticity
The development and function of neural circuits is dependent on the coordinated expression of molecules that control how neurons develop the dendritic arbor and postsynaptic dendritic spines. Dysregulation of critical ... -
Gene expression patterns of gammaherpesviruses
Gammaherpesviruses (γHVs) are lymphotropic oncogenic viruses which include the human pathogens Kaposi’s sarcoma associated herpesvirus (KSHV) and Epstein-Barr virus, as well as the murine model murine gammaherpesvirus 68 ... -
Practical issues in the design and analysis of stepped wedge cluster randomized trials
The stepped wedge (SW) design is a variation on the cluster randomized trial (CRT) in which all clusters receive both the control and intervention conditions. Clusters begin the trial at the same time, and all participants ... -
Role of lipid mediators in preclinical rheumatoid arthritis, The
Rheumatoid arthritis (RA) is the most common form of systemic autoimmune inflammatory arthritis (IA) and is characterized by excessive chronic inflammation, which suggests a failure in the ability to control or resolve ... -
Evaluating potential mechanisms of cardiovascular damage in women across the lifecourse
The risk of cardiovascular disease (CVD) is low in premenopausal women, but after menopause it increases to match that in men. Most of this increased risk has been attributed to loss of the favorable effects of endogenous ... -
Examining the relationship between nurse practitioner practice setting, practice environment, intrinsic motivation and attitudes about pay-for-performance financial incentives in Colorado
Abstract This study examined the relationship between nurse practitioner characteristics, practice setting, exposure to pay-for-performance (P4P) payment models, practice environment and intrinsic motivation on attitudes ... -
CD44 mediates cancer stem cell and macrophage/monocyte interactions in head and neck cancer progression via stemness to invasion switch
Tumor-associated macrophages (TAMs) at the tumor-stromal interface (TSI) cooperate with cancer stem cells (CSCs) to maintain stemness. However, the molecular mechanisms underlying crosstalk between TAMs and CSCs in head ... -
Risk factors for kaposi sarcoma-associated herpesvirus (KSHV) and kaposi sarcoma (KS) mortality in sub-Saharan Africa, The
The largest worldwide burden of Kaposi sarcoma (KS), 85% of all cases, is found in sub-Saharan Africa. Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent for KS. KSHV seroprevalence is inconsistent across ... -
Stories of the heart: illness narratives of veterans living with heart failure
Illness narratives for Veterans living with heart failure (HF) have been largely unexplored to date, yet HF is a significant and impactful illness affecting the lives of millions of Americans and Veterans. This study used ... -
Ion channel genetic biomarkers: diagnostic capabilities in the assessment of bipolar disorder
Background: Bipolar disorder is a commonly misdiagnosed mood disorder. When misdiagnosis occurs, consequences result from improper treatments. Genetic variants have been associated with bipolar disorder, but those variants ... -
Targeting the SIX1/EYA complex in breast cancer metastasis
Metastasis is the number 1 killer of cancer patients and mis-regulation of developmental signaling pathways can dramatically affect this process. The SIX1/EYA transcriptional complex, a master early development regulator, ... -
Transcriptional regulation of the developing retina
The retina is a complex stratified neural tissue required for all mammalian vision. During development, tightly controlled transcriptional regulation drives diversification from a homogenous population of retinal progenitor ... -
Brain circuits underlying sensorimotor transformations
Sensorimotor transformations are orchestrated across many brain regions to produce adaptive behavior. A chief goal of systems neuroscience is to understand the unique computations and contributions made within this network. ... -
Cerebellar control of reaching movements
Cerebellar dysfunction causes a unique decomposition of reaching movements, termed dysmetria. This oscillation of the limb during active movement is especially noticeable in the over- and under-shooting of target endpoint, ... -
Early determinants of CD8 T cell fate in the response to subunit immunization
While vaccination represents one of the most impactful developments in the history of medicine, successful vaccines still overwhelmingly rely on empirically-derived formulations targeting humoral responses. With the explosion ... -
Exploring stress and coping in caregivers of patients with a destination therapy left ventricular assist device: a mixed methods study
Family caregivers are essential in the delivery of care for patients with chronic illness. Caregivers are at risk for negative health outcomes due to stress, including increased morbidity and mortality. The way individuals ...
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