Computational and genomic methods to predict drug resistance in Mycobacterium tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) is the leading cause of death due to an infectious disease worldwide. There has been an upsurge in the emergence of multi drug resistant and extensively drug resistant strains of M. tb in recent years. M. tb exhibits varying degrees of drug resistance, often resulting from specific DNA mutations or variations affecting drug targets or drug activating enzymes, many of which result in amino acid changes. Rapid detection of drug resistant M. tb and the subsequent initiation of adequate treatment are imperative for effectively controlling ...
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