Targeting oxidative stress to attenuate seizure-induced neuroinflammation in temporal lobe epilepsy
Neuroinflammation is an extremely deleterious event considered to be a cause and consequence of prolonged seizures. The exact mechanisms contributing to hyperexcitability-induced neuroinflammation are not very well-defined. Understanding these mechanisms can lead to novel anti-epileptogenic therapies. Oxidative stress and consequent redox alterations are also thought to contribute to epileptogenesis. The purpose of this dissertation project was to investigate whether and how the glutathione (GSH) redox status and reactive oxygen species (ROS) contribute to neuroinflammation in cellular and animal ...
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